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Article: Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC)
Title | Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC) |
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Authors | |
Keywords | adenocarcinoma colon cancer hepatic resection propensity score matching rectal cancer |
Issue Date | 1-Dec-2022 |
Publisher | Wiley |
Citation | Journal of Surgical Oncology, 2022, v. 126, n. 7, p. 1242-1252 How to Cite? |
Abstract | Background: Resection of colorectal liver metastasis (CLM) is beneficial when feasible. However, the benefit of second hepatectomy for hepatic recurrence in CLM remains unclear. Methods: The Colorectal Liver Operative Metastasis International Collaborative retrospectively examined 1004 CLM cases from 2000 to 2018 from a total of 953 patients. Hepatic recurrence after initial hepatectomy was identified in 218 patients. Kaplan–Meier analysis was performed for overall survival (OS) and recurrence-free survival (RFS). Propensity score matching (PSM) was performed to offset selection bias. Cox proportional-hazards regression was performed to identify risk factors associated with OS. Results: A total of 51 patients underwent second hepatectomy. Unadjusted median OS was 60.1 months in repeat-hepatectomy versus 38.3 months in the single-hepatectomy group (p = 0.015). In the PSM population, median OS remained significantly better in the repeat-hepatectomy group (60.1 vs. 33.1 months; p = 0.0023); median RFS was 12.4 months for the repeat-hepatectomy group, versus 9.8 months in the single-hepatectomy group (p = 0.0050). Repeat hepatectomy was associated with lower risk of death (hazard ratio: 0.283; p = 0.000012). Obesity, tobacco use, and high intraoperative blood loss were associated with significant risk of death (p < 0.05). Conclusion: In CLM with hepatic recurrence, second hepatectomy was beneficial for OS. With PSM, the OS benefit of performing a second hepatectomy remained significant. |
Persistent Identifier | http://hdl.handle.net/10722/338782 |
ISSN | 2023 Impact Factor: 2.0 2023 SCImago Journal Rankings: 0.810 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Valenzuela, Cristian D | - |
dc.contributor.author | Moaven, Omeed | - |
dc.contributor.author | Gawdi, Rohin | - |
dc.contributor.author | Stauffer, John A | - |
dc.contributor.author | Del Piccolo, Nico R | - |
dc.contributor.author | Cheung, Tan To | - |
dc.contributor.author | Corvera, Carlos U | - |
dc.contributor.author | Wisneski, Andrew D | - |
dc.contributor.author | Cha, Charles | - |
dc.contributor.author | Pourhabibi Zarandi, Nima | - |
dc.contributor.author | Dourado, Justin | - |
dc.contributor.author | Perry, Kathleen C | - |
dc.contributor.author | Russell, Gregory | - |
dc.contributor.author | Shen, Perry | - |
dc.date.accessioned | 2024-03-11T10:31:29Z | - |
dc.date.available | 2024-03-11T10:31:29Z | - |
dc.date.issued | 2022-12-01 | - |
dc.identifier.citation | Journal of Surgical Oncology, 2022, v. 126, n. 7, p. 1242-1252 | - |
dc.identifier.issn | 0022-4790 | - |
dc.identifier.uri | http://hdl.handle.net/10722/338782 | - |
dc.description.abstract | <p> <span>Background: Resection of colorectal liver metastasis (CLM) is beneficial when feasible. However, the benefit of second hepatectomy for hepatic recurrence in CLM remains unclear. Methods: The Colorectal Liver Operative Metastasis International Collaborative retrospectively examined 1004 CLM cases from 2000 to 2018 from a total of 953 patients. Hepatic recurrence after initial hepatectomy was identified in 218 patients. Kaplan–Meier analysis was performed for overall survival (OS) and recurrence-free survival (RFS). Propensity score matching (PSM) was performed to offset selection bias. Cox proportional-hazards regression was performed to identify risk factors associated with OS. Results: A total of 51 patients underwent second hepatectomy. Unadjusted median OS was 60.1 months in repeat-hepatectomy versus 38.3 months in the single-hepatectomy group (p = 0.015). In the PSM population, median OS remained significantly better in the repeat-hepatectomy group (60.1 vs. 33.1 months; p = 0.0023); median RFS was 12.4 months for the repeat-hepatectomy group, versus 9.8 months in the single-hepatectomy group (p = 0.0050). Repeat hepatectomy was associated with lower risk of death (hazard ratio: 0.283; p = 0.000012). Obesity, tobacco use, and high intraoperative blood loss were associated with significant risk of death (p < 0.05). Conclusion: In CLM with hepatic recurrence, second hepatectomy was beneficial for OS. With PSM, the OS benefit of performing a second hepatectomy remained significant.</span> <br></p> | - |
dc.language | eng | - |
dc.publisher | Wiley | - |
dc.relation.ispartof | Journal of Surgical Oncology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | adenocarcinoma | - |
dc.subject | colon cancer | - |
dc.subject | hepatic resection | - |
dc.subject | propensity score matching | - |
dc.subject | rectal cancer | - |
dc.title | Outcomes after repeat hepatectomy for colorectal liver metastases from the colorectal liver operative metastasis international collaborative (COLOMIC) | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/jso.27056 | - |
dc.identifier.scopus | eid_2-s2.0-85135846411 | - |
dc.identifier.volume | 126 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1242 | - |
dc.identifier.epage | 1252 | - |
dc.identifier.eissn | 1096-9098 | - |
dc.identifier.isi | WOS:000840447500001 | - |
dc.identifier.issnl | 0022-4790 | - |