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Article: Reactive Oxygen Species‐Responsive Polymeric Prodrug Nanoparticles for Selective and Effective Treatment of Inflammatory Diseases

TitleReactive Oxygen Species‐Responsive Polymeric Prodrug Nanoparticles for Selective and Effective Treatment of Inflammatory Diseases
Authors
Keywordscinnamaldehyde
polymeric prodrugs
rheumatoid arthritis
ROS-responsive nanoparticles
ulcerative colitis
Issue Date4-Aug-2023
PublisherWiley
Citation
Advanced Healthcare Materials, 2023 How to Cite?
Abstract

It is challenging to manage inflammatory diseases using traditional anti-inflammatory drugs due to their limited efficacy and systemic side effects, which are a result of their lack of selectivity, poor stability, and low solubility. Herein, it reports the development of a novel nanoparticle system, called ROS-CA-NPs, which is formed using polymer-cinnamaldehyde (CA) conjugates and is responsive to reactive oxygen species (ROS). ROS-CA-NPs exhibit excellent drug stability, tissue selectivity, and controlled drug release upon oxidative stress activation. Using mouse models of chronic rheumatoid arthritis and acute ulcerative colitis, this study demonstrates that the systemic administration of ROS-CA-NPs results in their accumulation at inflamed lesions and leads to greater therapeutic efficacy compared to traditional drugs. Furthermore, ROS-CA-NPs present excellent biocompatibility. The findings suggest that ROS-CA-NPs have the potential to be developed as safe and effective nanotherapeutic agents for a broad range of inflammatory diseases.


Persistent Identifierhttp://hdl.handle.net/10722/338566
ISSN
2023 Impact Factor: 10.0
2023 SCImago Journal Rankings: 2.337
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yaming-
dc.contributor.authorLiu, Lu-
dc.contributor.authorWang, Tianyi-
dc.contributor.authorMao, Cong-
dc.contributor.authorShan, Pengfei-
dc.contributor.authorLau, Chak Sing-
dc.contributor.authorLi, Zhongyu-
dc.contributor.authorGuo, Weisheng-
dc.contributor.authorWang, Weiping -
dc.date.accessioned2024-03-11T10:29:51Z-
dc.date.available2024-03-11T10:29:51Z-
dc.date.issued2023-08-04-
dc.identifier.citationAdvanced Healthcare Materials, 2023-
dc.identifier.issn2192-2640-
dc.identifier.urihttp://hdl.handle.net/10722/338566-
dc.description.abstract<p>It is challenging to manage inflammatory diseases using traditional anti-inflammatory drugs due to their limited efficacy and systemic side effects, which are a result of their lack of selectivity, poor stability, and low solubility. Herein, it reports the development of a novel nanoparticle system, called ROS-CA-NPs, which is formed using polymer-cinnamaldehyde (CA) conjugates and is responsive to reactive oxygen species (ROS). ROS-CA-NPs exhibit excellent drug stability, tissue selectivity, and controlled drug release upon oxidative stress activation. Using mouse models of chronic rheumatoid arthritis and acute ulcerative colitis, this study demonstrates that the systemic administration of ROS-CA-NPs results in their accumulation at inflamed lesions and leads to greater therapeutic efficacy compared to traditional drugs. Furthermore, ROS-CA-NPs present excellent biocompatibility. The findings suggest that ROS-CA-NPs have the potential to be developed as safe and effective nanotherapeutic agents for a broad range of inflammatory diseases.</p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofAdvanced Healthcare Materials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcinnamaldehyde-
dc.subjectpolymeric prodrugs-
dc.subjectrheumatoid arthritis-
dc.subjectROS-responsive nanoparticles-
dc.subjectulcerative colitis-
dc.titleReactive Oxygen Species‐Responsive Polymeric Prodrug Nanoparticles for Selective and Effective Treatment of Inflammatory Diseases-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/adhm.202301394-
dc.identifier.scopuseid_2-s2.0-85168287771-
dc.identifier.eissn2192-2659-
dc.identifier.isiWOS:001049841600001-
dc.identifier.issnl2192-2640-

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