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Article: Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction
Title | Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction |
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Authors | |
Keywords | cellular force ECM dynamics engineering biomaterials matrix mechanics mechanotransduction |
Issue Date | 24-Mar-2023 |
Publisher | Wiley-VCH |
Citation | Advanced Science, 2023, v. 10, n. 9 How to Cite? |
Abstract | The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell culture biomaterials, with static mechanical properties such as chemistry, topography, and stiffness, have offered a fundamental understanding of various vital biochemical and biophysical processes, such as cell adhesion, spreading, migration, growth, and differentiation. At present, novel biomaterials that can spatiotemporally impart biophysical cues to manipulate cell fate are emerging. The dynamic properties and adaptive traits of new materials endow them with the ability to adapt to cell requirements and enhance cell functions. In this review, an introductory overview of the key players essential to mechanobiology is provided. A biophysical perspective on the state-of-the-art manipulation techniques and novel materials in designing static and dynamic ECM-mimicking biomaterials is taken. In particular, different static and dynamic mechanical cues in regulating cellular mechanosensing and functions are compared. This review to benefit the development of engineering biomechanical systems regulating cell functions is expected. |
Persistent Identifier | http://hdl.handle.net/10722/338426 |
ISSN | 2023 Impact Factor: 14.3 2023 SCImago Journal Rankings: 3.914 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xie, Wenyan | - |
dc.contributor.author | Wei, Xi | - |
dc.contributor.author | Kang, Heemin | - |
dc.contributor.author | Jiang, Hong | - |
dc.contributor.author | Chu, Zhiqin | - |
dc.contributor.author | Lin, Yuan | - |
dc.contributor.author | Hou, Yong | - |
dc.contributor.author | Wei, Qiang | - |
dc.date.accessioned | 2024-03-11T10:28:47Z | - |
dc.date.available | 2024-03-11T10:28:47Z | - |
dc.date.issued | 2023-03-24 | - |
dc.identifier.citation | Advanced Science, 2023, v. 10, n. 9 | - |
dc.identifier.issn | 2198-3844 | - |
dc.identifier.uri | http://hdl.handle.net/10722/338426 | - |
dc.description.abstract | <p>The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell culture biomaterials, with static mechanical properties such as chemistry, topography, and stiffness, have offered a fundamental understanding of various vital biochemical and biophysical processes, such as cell adhesion, spreading, migration, growth, and differentiation. At present, novel biomaterials that can spatiotemporally impart biophysical cues to manipulate cell fate are emerging. The dynamic properties and adaptive traits of new materials endow them with the ability to adapt to cell requirements and enhance cell functions. In this review, an introductory overview of the key players essential to mechanobiology is provided. A biophysical perspective on the state-of-the-art manipulation techniques and novel materials in designing static and dynamic ECM-mimicking biomaterials is taken. In particular, different static and dynamic mechanical cues in regulating cellular mechanosensing and functions are compared. This review to benefit the development of engineering biomechanical systems regulating cell functions is expected.<br></p> | - |
dc.language | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.ispartof | Advanced Science | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | cellular force | - |
dc.subject | ECM dynamics | - |
dc.subject | engineering biomaterials | - |
dc.subject | matrix mechanics | - |
dc.subject | mechanotransduction | - |
dc.title | Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/advs.202204594 | - |
dc.identifier.scopus | eid_2-s2.0-85147021128 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 9 | - |
dc.identifier.eissn | 2198-3844 | - |
dc.identifier.isi | WOS:000913864300001 | - |
dc.identifier.issnl | 2198-3844 | - |