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- Publisher Website: 10.1016/j.celrep.2022.110884
- Scopus: eid_2-s2.0-85131120129
- PMID: 35649375
- WOS: WOS:000817770200004
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Article: Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine.
Title | Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine. |
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Authors | |
Keywords | adenosine kinase (ADK) AMPK CP: Metabolism diabetes equilibrative nucleoside transporter (ENT) extracellular adenosine extracellular AMP mTORC1 muscle satellite cells (MuSCs) |
Issue Date | 31-May-2022 |
Publisher | Cell Press |
Citation | Cell Reports, 2022, v. 39, n. 9 How to Cite? |
Abstract | Muscle regeneration is known to be defective under diabetic conditions. However, the underlying mechanisms remain less clear. Adult quiescent muscle satellite cells (MuSCs) from leptin-receptor-deficient (i.e., db/db) diabetic mice are defective in early activation in vivo, but not in culture, suggesting the involvement of pathogenic niche factors. Elevated extracellular adenosine (eAdo) and AMP (eAMP) are detected under diabetic conditions. eAdo and eAMP potently inhibit cell cycle re-entry of quiescent MuSCs and injury-induced muscle regeneration. Mechanistically, eAdo and eAMP engage the equilibrative Ado transporters (ENTs)-Ado kinase (ADK)-AMPK signaling axis in MuSCs to inhibit the mTORC1-dependent cell growth checkpoint. eAdo and eAMP also inhibit early activation of quiescent fibroadipogenic progenitors and human MuSCs by the same mechanism. Treatment of db/db diabetic mice with an ADK inhibitor partially rescues the activation defects of MuSCs in vivo. Thus, both ADK and ENTs represent potential therapeutic targets for restoring the regenerative functions of tissue stem cells in patients with diabetes. |
Persistent Identifier | http://hdl.handle.net/10722/338285 |
ISSN | 2023 Impact Factor: 7.5 2023 SCImago Journal Rankings: 4.279 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Han, L | - |
dc.contributor.author | Wang, G | - |
dc.contributor.author | Zhou, S | - |
dc.contributor.author | Situ, C | - |
dc.contributor.author | He, Z | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Qiu, Y | - |
dc.contributor.author | Huang, Y | - |
dc.contributor.author | Xu, A | - |
dc.contributor.author | Ong, MTY | - |
dc.contributor.author | Wang, H | - |
dc.contributor.author | Zhang, J | - |
dc.contributor.author | Wu, Z | - |
dc.date.accessioned | 2024-03-11T10:27:43Z | - |
dc.date.available | 2024-03-11T10:27:43Z | - |
dc.date.issued | 2022-05-31 | - |
dc.identifier.citation | Cell Reports, 2022, v. 39, n. 9 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10722/338285 | - |
dc.description.abstract | <p>Muscle regeneration is known to be defective under diabetic conditions. However, the underlying mechanisms remain less clear. Adult quiescent muscle satellite cells (MuSCs) from leptin-receptor-deficient (i.e., db/db) diabetic mice are defective in early activation in vivo, but not in culture, suggesting the involvement of pathogenic niche factors. Elevated extracellular adenosine (eAdo) and AMP (eAMP) are detected under diabetic conditions. eAdo and eAMP potently inhibit cell cycle re-entry of quiescent MuSCs and injury-induced muscle regeneration. Mechanistically, eAdo and eAMP engage the equilibrative Ado transporters (ENTs)-Ado kinase (ADK)-AMPK signaling axis in MuSCs to inhibit the mTORC1-dependent cell growth checkpoint. eAdo and eAMP also inhibit early activation of quiescent fibroadipogenic progenitors and human MuSCs by the same mechanism. Treatment of db/db diabetic mice with an ADK inhibitor partially rescues the activation defects of MuSCs in vivo. Thus, both ADK and ENTs represent potential therapeutic targets for restoring the regenerative functions of tissue stem cells in patients with diabetes.</p> | - |
dc.language | eng | - |
dc.publisher | Cell Press | - |
dc.relation.ispartof | Cell Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | adenosine kinase (ADK) | - |
dc.subject | AMPK | - |
dc.subject | CP: Metabolism | - |
dc.subject | diabetes | - |
dc.subject | equilibrative nucleoside transporter (ENT) | - |
dc.subject | extracellular adenosine | - |
dc.subject | extracellular AMP | - |
dc.subject | mTORC1 | - |
dc.subject | muscle satellite cells (MuSCs) | - |
dc.title | Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine. | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.celrep.2022.110884 | - |
dc.identifier.pmid | 35649375 | - |
dc.identifier.scopus | eid_2-s2.0-85131120129 | - |
dc.identifier.volume | 39 | - |
dc.identifier.issue | 9 | - |
dc.identifier.eissn | 2211-1247 | - |
dc.identifier.isi | WOS:000817770200004 | - |
dc.identifier.issnl | 2211-1247 | - |