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Article: Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions

TitleComparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions
Authors
KeywordsiBAT
immune cells
MRI
Rabbit
transcriptomic analysis
whitening
Issue Date31-Dec-2022
PublisherTaylor and Francis Group
Citation
Adipocyte, 2022, v. 11, n. 1, p. 529-549 How to Cite?
AbstractInterscapular brown adipose tissue (iBAT) of both rabbits and humans exhibits a similar whitening phenomenon under physiological conditions. However, a detailed characterization of iBAT whitening in them is still lacking. Here, we chose rabbits as a model to gain a better understanding of the molecular signature changes during the whitening process of iBAT by transcriptomic analysis of rabbit iBAT at day 1, day 14, 1 month and 4 months after birth. We applied non-invasive MRI imaging to monitor the whitening process and correlated these changes with analysis of morphological, histological and molecular features. Principal component analysis (PCA) of differentially expressed genes delineated three major phases for the whitening process as Brown, Transition and Whitened BAT phases. RNA-sequencing data revealed that whitening of iBAT was an orchestrated process where multiple types of cells and tissues participated in a variety of physiological processes including neovascularization, formation of new nervous networks and immune regulation. Several key metabolic and signalling pathways contributed to whitening of iBAT, and immune cells and immune regulation appeared to play an overarching role.
Persistent Identifierhttp://hdl.handle.net/10722/338257
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 0.960
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, L-
dc.contributor.authorWan, Q-
dc.contributor.authorLong, QY-
dc.contributor.authorNie, T-
dc.contributor.authorZhao, ST-
dc.contributor.authorMao, LF-
dc.contributor.authorCheng, CL-
dc.contributor.authorZou, C-
dc.contributor.authorLoomes, K-
dc.contributor.authorXu, AM-
dc.contributor.authorLai, LX-
dc.contributor.authorLiu, X-
dc.contributor.authorDuan, ZY-
dc.contributor.authorHui, XY-
dc.contributor.authorWu, DH -
dc.date.accessioned2024-03-11T10:27:28Z-
dc.date.available2024-03-11T10:27:28Z-
dc.date.issued2022-12-31-
dc.identifier.citationAdipocyte, 2022, v. 11, n. 1, p. 529-549-
dc.identifier.issn2162-3945-
dc.identifier.urihttp://hdl.handle.net/10722/338257-
dc.description.abstractInterscapular brown adipose tissue (iBAT) of both rabbits and humans exhibits a similar whitening phenomenon under physiological conditions. However, a detailed characterization of iBAT whitening in them is still lacking. Here, we chose rabbits as a model to gain a better understanding of the molecular signature changes during the whitening process of iBAT by transcriptomic analysis of rabbit iBAT at day 1, day 14, 1 month and 4 months after birth. We applied non-invasive MRI imaging to monitor the whitening process and correlated these changes with analysis of morphological, histological and molecular features. Principal component analysis (PCA) of differentially expressed genes delineated three major phases for the whitening process as Brown, Transition and Whitened BAT phases. RNA-sequencing data revealed that whitening of iBAT was an orchestrated process where multiple types of cells and tissues participated in a variety of physiological processes including neovascularization, formation of new nervous networks and immune regulation. Several key metabolic and signalling pathways contributed to whitening of iBAT, and immune cells and immune regulation appeared to play an overarching role.-
dc.languageeng-
dc.publisherTaylor and Francis Group-
dc.relation.ispartofAdipocyte-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectiBAT-
dc.subjectimmune cells-
dc.subjectMRI-
dc.subjectRabbit-
dc.subjecttranscriptomic analysis-
dc.subjectwhitening-
dc.titleComparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1080/21623945.2022.2111053-
dc.identifier.pmid36000239-
dc.identifier.scopuseid_2-s2.0-85137999446-
dc.identifier.volume11-
dc.identifier.issue1-
dc.identifier.spage529-
dc.identifier.epage549-
dc.identifier.eissn2162-397X-
dc.identifier.isiWOS:000847241400001-
dc.publisher.placePHILADELPHIA-
dc.identifier.issnl2162-3945-

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