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- Publisher Website: 10.1007/978-1-0716-2695-5_20
- Scopus: eid_2-s2.0-85138660517
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Book Chapter: Robotic APTamer-Enabled Electrochemical Reader (RAPTER) System for Automated Aptamer-Mediated Electrochemical Analysis
| Title | Robotic APTamer-Enabled Electrochemical Reader (RAPTER) System for Automated Aptamer-Mediated Electrochemical Analysis |
|---|---|
| Authors | |
| Keywords | Aptamer Aptasensor Automated analysis Biosensor Electrochemical aptamer-based Liquid-handling robot Luteinizing hormone Opentron RAPTER Squarewave voltammetry |
| Issue Date | 27-Sep-2022 |
| Publisher | Humana Press, Inc. |
| Abstract | Electrochemical aptamer-based (E-AB) sensors using conformational change-induced electron transfer kinetics are sensitive, reagent-less, and cost-effective tools for molecular sensing. Current advances in this technology can allow continuous drug pharmacokinetic monitoring in living animals (Dauphin-Ducharme et al., ACS Sens 4(10):2832–2837, 2019; Idili et al., Chem Sci 10(35):8164–8170, 2019), as well as automated analysis of hormone pulsatility (Liang et al., Nat Commun 10(1):852, 2019). In this chapter, we provide the methodology for an automated E-AB conformational change-based robotic sensing platform. By using an open-source programmable robotic system, this method can be adapted to a wide range of experimental scenarios. |
| Persistent Identifier | http://hdl.handle.net/10722/338069 |
| ISBN | |
| ISSN | 2020 SCImago Journal Rankings: 0.711 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lo, Young | - |
| dc.contributor.author | Liang, Shaolin | - |
| dc.contributor.author | Dhillo, Waljit S | - |
| dc.contributor.author | Cass, Anthony E G | - |
| dc.contributor.author | Tanner, Julian A | - |
| dc.date.accessioned | 2024-03-11T10:26:01Z | - |
| dc.date.available | 2024-03-11T10:26:01Z | - |
| dc.date.issued | 2022-09-27 | - |
| dc.identifier.isbn | 9781071626948 | - |
| dc.identifier.issn | 1064-3745 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/338069 | - |
| dc.description.abstract | <p>Electrochemical aptamer-based (E-AB) sensors using conformational change-induced electron transfer kinetics are sensitive, reagent-less, and cost-effective tools for molecular sensing. Current advances in this technology can allow continuous drug pharmacokinetic monitoring in living animals (Dauphin-Ducharme et al., ACS Sens 4(10):2832–2837, 2019; Idili et al., Chem Sci 10(35):8164–8170, 2019), as well as automated analysis of hormone pulsatility (Liang et al., Nat Commun 10(1):852, 2019). In this chapter, we provide the methodology for an automated E-AB conformational change-based robotic sensing platform. By using an open-source programmable robotic system, this method can be adapted to a wide range of experimental scenarios.<br></p> | - |
| dc.language | eng | - |
| dc.publisher | Humana Press, Inc. | - |
| dc.relation.ispartof | Methods in molecular biology | - |
| dc.subject | Aptamer | - |
| dc.subject | Aptasensor | - |
| dc.subject | Automated analysis | - |
| dc.subject | Biosensor | - |
| dc.subject | Electrochemical aptamer-based | - |
| dc.subject | Liquid-handling robot | - |
| dc.subject | Luteinizing hormone | - |
| dc.subject | Opentron | - |
| dc.subject | RAPTER | - |
| dc.subject | Squarewave voltammetry | - |
| dc.title | Robotic APTamer-Enabled Electrochemical Reader (RAPTER) System for Automated Aptamer-Mediated Electrochemical Analysis | - |
| dc.type | Book_Chapter | - |
| dc.identifier.doi | 10.1007/978-1-0716-2695-5_20 | - |
| dc.identifier.scopus | eid_2-s2.0-85138660517 | - |
| dc.identifier.volume | 2570 | - |
| dc.identifier.spage | 271 | - |
| dc.identifier.epage | 280 | - |
| dc.identifier.eissn | 1940-6029 | - |
| dc.identifier.eisbn | 9781071626955 | - |
| dc.identifier.issnl | 1064-3745 | - |