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- Publisher Website: 10.3390/biology11071063
- Scopus: eid_2-s2.0-85136287238
- WOS: WOS:000832308200001
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Article: Is Brain-Derived Neurotrophic Factor a Metabolic Hormone in Peripheral Tissues?
Title | Is Brain-Derived Neurotrophic Factor a Metabolic Hormone in Peripheral Tissues? |
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Authors | |
Keywords | BDNF metabolism mitochondria peripheral tissues |
Issue Date | 17-Jul-2022 |
Publisher | MDPI |
Citation | Biology, 2022, v. 11, n. 7 How to Cite? |
Abstract | Brain-derived neurotrophic factor (BDNF) is an important growth factor in the central nervous system. In addition to its well-known activities in promoting neuronal survival, neuron differentiation, and synaptic plasticity, neuronal BDNF also regulates energy homeostasis by modulating the hypothalamus's hormonal signals. In the past decades, several peripheral tissues, including liver, skeletal muscle, and white adipose tissue, were demonstrated as the active sources of BDNF synthesis in response to different metabolic challenges. Nevertheless, the functions of BDNF in these tissues remain obscure. With the use of tissue-specific Bdnf knockout animals and the availability of non-peptidyl BDNF mimetic, increasing evidence has reported that peripheral tissues-derived BDNF might play a significant role in maintaining systemic metabolism, possibly through the regulation of mitochondrial dynamics in the various tissues. This article reviews the autocrine/paracrine/endocrine functions of BDNF in non-neuronal tissues and discusses the unresolved questions about BDNF's function. |
Persistent Identifier | http://hdl.handle.net/10722/337938 |
ISSN | 2021 Impact Factor: 5.168 2020 SCImago Journal Rankings: 1.731 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Iu, Elsie Chit Yu | - |
dc.contributor.author | Chan, Chi Bun | - |
dc.date.accessioned | 2024-03-11T10:25:03Z | - |
dc.date.available | 2024-03-11T10:25:03Z | - |
dc.date.issued | 2022-07-17 | - |
dc.identifier.citation | Biology, 2022, v. 11, n. 7 | - |
dc.identifier.issn | 2079-7737 | - |
dc.identifier.uri | http://hdl.handle.net/10722/337938 | - |
dc.description.abstract | <p>Brain-derived neurotrophic factor (BDNF) is an important growth factor in the central nervous system. In addition to its well-known activities in promoting neuronal survival, neuron differentiation, and synaptic plasticity, neuronal BDNF also regulates energy homeostasis by modulating the hypothalamus's hormonal signals. In the past decades, several peripheral tissues, including liver, skeletal muscle, and white adipose tissue, were demonstrated as the active sources of BDNF synthesis in response to different metabolic challenges. Nevertheless, the functions of BDNF in these tissues remain obscure. With the use of tissue-specific Bdnf knockout animals and the availability of non-peptidyl BDNF mimetic, increasing evidence has reported that peripheral tissues-derived BDNF might play a significant role in maintaining systemic metabolism, possibly through the regulation of mitochondrial dynamics in the various tissues. This article reviews the autocrine/paracrine/endocrine functions of BDNF in non-neuronal tissues and discusses the unresolved questions about BDNF's function.</p> | - |
dc.language | eng | - |
dc.publisher | MDPI | - |
dc.relation.ispartof | Biology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | BDNF | - |
dc.subject | metabolism | - |
dc.subject | mitochondria | - |
dc.subject | peripheral tissues | - |
dc.title | Is Brain-Derived Neurotrophic Factor a Metabolic Hormone in Peripheral Tissues? | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/biology11071063 | - |
dc.identifier.scopus | eid_2-s2.0-85136287238 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 7 | - |
dc.identifier.eissn | 2079-7737 | - |
dc.identifier.isi | WOS:000832308200001 | - |
dc.identifier.issnl | 2079-7737 | - |