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Article: Cell-Mimic Directional Cargo Transportation in a Visible-Light-Activated Colloidal Motor/Lipid Tube System

TitleCell-Mimic Directional Cargo Transportation in a Visible-Light-Activated Colloidal Motor/Lipid Tube System
Authors
Keywordsactive transportation
cell-mimicking
colloidal motors
giant unilamellar vesicles
lipid tubes
Issue Date24-Nov-2022
PublisherWiley
Citation
Small, 2023, v. 19, n. 5 How to Cite?
AbstractActive tether and transportation of cargoes on cytoskeletal highway enabled by molecular motors is key for accurate delivery of vesicles and organelles in the complex intracellular environment. Here, a hybrid system composed of colloidal motors and self-assembled lipid tubes is designed to mimic the subcellular traffic system in living cells. The colloidal motors, composed of gold-coated hematite, display light-activated self-propulsion tunable by the light intensity and the concentration of hydrogen peroxide fuel. Importantly, the motors show light-switchable binding with lipid cargoes and attachment to the lipid tubes, whereby the latter act as the motor highways. Upon assembly, the colloidal motor/lipid tube system demonstrates directional delivery of lipid vesicles, emulating intracellular transportation. The assembly and function of the hybrid system are rationalized by a cooperative action of light-triggered electrophoretic and hydrodynamic effects, supported by finite element analysis. A synthetic analog of the biological protein motor/cytoskeletal filament system is realized for the manipulation and delivery of different matter at the microscale, which is expected to be a promising platform for various applications in materials science, nanotechnology, microfluidics, and synthetic biology.
Persistent Identifierhttp://hdl.handle.net/10722/337896
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 3.348
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGhellab, SE-
dc.contributor.authorZhang, XY-
dc.contributor.authorYang, YC-
dc.contributor.authorWang, S-
dc.contributor.authorBasharat, M-
dc.contributor.authorZhou, XM-
dc.contributor.authorLei, LJ-
dc.contributor.authorZhou, Y-
dc.contributor.authorWang, YF-
dc.contributor.authorFang, H-
dc.contributor.authorGao, YX-
dc.date.accessioned2024-03-11T10:24:44Z-
dc.date.available2024-03-11T10:24:44Z-
dc.date.issued2022-11-24-
dc.identifier.citationSmall, 2023, v. 19, n. 5-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/337896-
dc.description.abstractActive tether and transportation of cargoes on cytoskeletal highway enabled by molecular motors is key for accurate delivery of vesicles and organelles in the complex intracellular environment. Here, a hybrid system composed of colloidal motors and self-assembled lipid tubes is designed to mimic the subcellular traffic system in living cells. The colloidal motors, composed of gold-coated hematite, display light-activated self-propulsion tunable by the light intensity and the concentration of hydrogen peroxide fuel. Importantly, the motors show light-switchable binding with lipid cargoes and attachment to the lipid tubes, whereby the latter act as the motor highways. Upon assembly, the colloidal motor/lipid tube system demonstrates directional delivery of lipid vesicles, emulating intracellular transportation. The assembly and function of the hybrid system are rationalized by a cooperative action of light-triggered electrophoretic and hydrodynamic effects, supported by finite element analysis. A synthetic analog of the biological protein motor/cytoskeletal filament system is realized for the manipulation and delivery of different matter at the microscale, which is expected to be a promising platform for various applications in materials science, nanotechnology, microfluidics, and synthetic biology.-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofSmall-
dc.subjectactive transportation-
dc.subjectcell-mimicking-
dc.subjectcolloidal motors-
dc.subjectgiant unilamellar vesicles-
dc.subjectlipid tubes-
dc.titleCell-Mimic Directional Cargo Transportation in a Visible-Light-Activated Colloidal Motor/Lipid Tube System-
dc.typeArticle-
dc.identifier.doi10.1002/smll.202204260-
dc.identifier.pmid36424173-
dc.identifier.scopuseid_2-s2.0-85142665523-
dc.identifier.volume19-
dc.identifier.issue5-
dc.identifier.eissn1613-6829-
dc.identifier.isiWOS:000889998700001-
dc.publisher.placeWEINHEIM-
dc.identifier.issnl1613-6810-

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