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Article: Identification of injury type using somatosensory and motor evoked potentials in a rat spinal cord injury model

TitleIdentification of injury type using somatosensory and motor evoked potentials in a rat spinal cord injury model
Authors
Keywordscontusion injury
dislocation injury
distraction injury
electrophysiology
heterogeneity
histopathology
injury mechanism
motor evoked potential
somatosensory evoked potential
spinal cord injury
Issue Date1-Feb-2023
PublisherMedknow Publications
Citation
Neural Regeneration Research, 2023, v. 18, n. 2, p. 422-427 How to Cite?
Abstract

The spinal cord is at risk of injury during spinal surgery. If intraoperative spinal cord injury is identified early, irreversible impairment or loss of neurological function can be prevented. Different types of spinal cord injury result in damage to different spinal cord regions, which may cause different somatosensory and motor evoked potential signal responses. In this study, we examined electrophysiological and histopathological changes between contusion, distraction, and dislocation spinal cord injuries in a rat model. We found that contusion led to the most severe dorsal white matter injury and caused considerable attenuation of both somatosensory and motor evoked potentials. Dislocation resulted in loss of myelinated axons in the lateral region of the injured spinal cord along the rostrocaudal axis. The amplitude of attenuation in motor evoked potential responses caused by dislocation was greater than that caused by contusion. After distraction injury, extracellular spaces were slightly but not significantly enlarged; somatosensory evoked potential responses slightly decreased and motor evoked potential responses were lost. Correlation analysis showed that histological and electrophysiological findings were significantly correlated and related to injury type. Intraoperative monitoring of both somatosensory and motor evoked potentials has the potential to identify iatrogenic spinal cord injury type during surgery.


Persistent Identifierhttp://hdl.handle.net/10722/337848
ISSN
2023 Impact Factor: 5.9
2023 SCImago Journal Rankings: 0.967
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Rong-
dc.contributor.authorLi, Han-Lei-
dc.contributor.authorCui, Hong-Yan-
dc.contributor.authorHuang Yong-Can-
dc.contributor.authorHu, Yong-
dc.date.accessioned2024-03-11T10:24:21Z-
dc.date.available2024-03-11T10:24:21Z-
dc.date.issued2023-02-01-
dc.identifier.citationNeural Regeneration Research, 2023, v. 18, n. 2, p. 422-427-
dc.identifier.issn1673-5374-
dc.identifier.urihttp://hdl.handle.net/10722/337848-
dc.description.abstract<p>The spinal cord is at risk of injury during spinal surgery. If intraoperative spinal cord injury is identified early, irreversible impairment or loss of neurological function can be prevented. Different types of spinal cord injury result in damage to different spinal cord regions, which may cause different somatosensory and motor evoked potential signal responses. In this study, we examined electrophysiological and histopathological changes between contusion, distraction, and dislocation spinal cord injuries in a rat model. We found that contusion led to the most severe dorsal white matter injury and caused considerable attenuation of both somatosensory and motor evoked potentials. Dislocation resulted in loss of myelinated axons in the lateral region of the injured spinal cord along the rostrocaudal axis. The amplitude of attenuation in motor evoked potential responses caused by dislocation was greater than that caused by contusion. After distraction injury, extracellular spaces were slightly but not significantly enlarged; somatosensory evoked potential responses slightly decreased and motor evoked potential responses were lost. Correlation analysis showed that histological and electrophysiological findings were significantly correlated and related to injury type. Intraoperative monitoring of both somatosensory and motor evoked potentials has the potential to identify iatrogenic spinal cord injury type during surgery.</p>-
dc.languageeng-
dc.publisherMedknow Publications-
dc.relation.ispartofNeural Regeneration Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcontusion injury-
dc.subjectdislocation injury-
dc.subjectdistraction injury-
dc.subjectelectrophysiology-
dc.subjectheterogeneity-
dc.subjecthistopathology-
dc.subjectinjury mechanism-
dc.subjectmotor evoked potential-
dc.subjectsomatosensory evoked potential-
dc.subjectspinal cord injury-
dc.titleIdentification of injury type using somatosensory and motor evoked potentials in a rat spinal cord injury model-
dc.typeArticle-
dc.identifier.doi10.4103/1673-5374.346458-
dc.identifier.scopuseid_2-s2.0-85135466266-
dc.identifier.volume18-
dc.identifier.issue2-
dc.identifier.spage422-
dc.identifier.epage427-
dc.identifier.eissn1876-7958-
dc.identifier.isiWOS:000834672700045-
dc.identifier.issnl1673-5374-

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