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- Publisher Website: 10.1016/j.jad.2023.04.082
- Scopus: eid_2-s2.0-85153406413
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Article: Habenula functional connectivity variability increases with disease severity in individuals with major depression
Title | Habenula functional connectivity variability increases with disease severity in individuals with major depression |
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Authors | |
Keywords | Dynamic functional connectivity Functional magnetic resonance imaging Habenula Major depressive disorder |
Issue Date | 26-May-2023 |
Publisher | Elsevier |
Citation | Journal of Affective Disorders, 2023, v. 333, p. 216-224 How to Cite? |
Abstract | Background: Increasing evidence has suggested the significant relationships between major depressive disorder (MDD) and the neural abnormalities of the Habenula (Hb). Yet, previous research on the relationships between Hb and MDD mainly focuses on the static descriptions of their functional connectivity. However, recent work suggests that the connectivity patterns are indeed dynamic, though related analysis and interpretation remain scarce.Methods: Using seed-based resting-state fMRI, the static (sFC) and dynamic functional connectivity (dFC) be- tween the Hb and whole-brain were calculated, including 51 clinical participants (MDDs) and 45 healthy controls (HCs). Association between the aberrant connectivity patterns and depressive symptomatology was also analyzed.Results: Compared with the HCs, MDDs exhibited increased sFC from the left Hb to the right inferior temporal gyrus and left superior frontal gyrus (SFG), while sFC to the right calcarine gyrus decreased. Notably, we observed that dFC between the left Hb and the right supplementary motor area, right postcentral gyrus (PoCG), left inferior frontal gyrus as well as left occipital gyrus was weak in MDDs. Furthermore, sFC between the Hb and SFG correlated positively with the measured attention-related cognitive deficits. Importantly, there was a pos- itive correlation between dFC between the Hb and PoCG and depressive severity.Conclusions: The findings indicate that the anomalous neural circuitry of Hb may underpin impaired attention disengagement, emotional modulation and motor inhibition associated with depressive symptoms such as rumination disposition and psychomotor retardation. This may open new avenues for studying the neuropa- thology mechanisms and guiding new treatment strategies for MDD. |
Persistent Identifier | http://hdl.handle.net/10722/337695 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 2.082 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhu, Ziqing | - |
dc.contributor.author | Wang, Sibin | - |
dc.contributor.author | Lee, Tatia MC | - |
dc.contributor.author | Zhang, Ruibin | - |
dc.date.accessioned | 2024-03-11T10:23:09Z | - |
dc.date.available | 2024-03-11T10:23:09Z | - |
dc.date.issued | 2023-05-26 | - |
dc.identifier.citation | Journal of Affective Disorders, 2023, v. 333, p. 216-224 | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.uri | http://hdl.handle.net/10722/337695 | - |
dc.description.abstract | <p>Background: Increasing evidence has suggested the significant relationships between major depressive disorder (MDD) and the neural abnormalities of the Habenula (Hb). Yet, previous research on the relationships between Hb and MDD mainly focuses on the static descriptions of their functional connectivity. However, recent work suggests that the connectivity patterns are indeed dynamic, though related analysis and interpretation remain scarce.Methods: Using seed-based resting-state fMRI, the static (sFC) and dynamic functional connectivity (dFC) be- tween the Hb and whole-brain were calculated, including 51 clinical participants (MDDs) and 45 healthy controls (HCs). Association between the aberrant connectivity patterns and depressive symptomatology was also analyzed.Results: Compared with the HCs, MDDs exhibited increased sFC from the left Hb to the right inferior temporal gyrus and left superior frontal gyrus (SFG), while sFC to the right calcarine gyrus decreased. Notably, we observed that dFC between the left Hb and the right supplementary motor area, right postcentral gyrus (PoCG), left inferior frontal gyrus as well as left occipital gyrus was weak in MDDs. Furthermore, sFC between the Hb and SFG correlated positively with the measured attention-related cognitive deficits. Importantly, there was a pos- itive correlation between dFC between the Hb and PoCG and depressive severity.Conclusions: The findings indicate that the anomalous neural circuitry of Hb may underpin impaired attention disengagement, emotional modulation and motor inhibition associated with depressive symptoms such as rumination disposition and psychomotor retardation. This may open new avenues for studying the neuropa- thology mechanisms and guiding new treatment strategies for MDD.<br></p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Journal of Affective Disorders | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Dynamic functional connectivity | - |
dc.subject | Functional magnetic resonance imaging | - |
dc.subject | Habenula | - |
dc.subject | Major depressive disorder | - |
dc.title | Habenula functional connectivity variability increases with disease severity in individuals with major depression | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jad.2023.04.082 | - |
dc.identifier.scopus | eid_2-s2.0-85153406413 | - |
dc.identifier.volume | 333 | - |
dc.identifier.spage | 216 | - |
dc.identifier.epage | 224 | - |
dc.identifier.eissn | 1573-2517 | - |
dc.identifier.isi | WOS:000987954800001 | - |
dc.identifier.issnl | 0165-0327 | - |