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Article: A neural-related gene risk score for head and neck squamous cell carcinoma

TitleA neural-related gene risk score for head and neck squamous cell carcinoma
Authors
Keywordshead and neck cancer
immunotherapy
nerve-cancer crosstalk
overall survival
prognostic signature
Issue Date21-Nov-2022
PublisherWiley
Citation
Oral Diseases, 2022 How to Cite?
AbstractObjectivesThis study aimed to establish a neural-related gene risk score (NRGRS) for the prediction of head and neck squamous cell carcinoma prognosis and explore its predictive value on the benefit of immune checkpoint inhibitor therapy. MethodsBased on the transcriptome data of HNSCC patients (n = 546) from The Cancer Genome Atlas database, 37 neural-related hub genes were identified by weighted gene co-expression network analysis. Four genes (ITGA5, PYGM, GNG7 and ATP2A3) were identified to construct NRGRS using Lasso-Cox regression method based on the derivation cohort and validated in the Gene Expression Omnibus cohort (n = 109). The survival analysis was performed to validate the prognostic value of NRGRS and immune characteristics in NRGRS-defined subgroups were analyzed. ResultsNRGRS-high patients had a worse overall survival than NRGRS-low patients. Tumors with high NRGRS were more likely to have high infiltration of naive CD4(+) T cells, M0, M2 macrophages and resting mast cells, which illustrated suppressive immunity and less benefit from immunotherapy therapy. ConclusionNRGRS strongly correlates with survival and is a promising biomarker to predict immunotherapy benefits for head and neck cancer patients. This study provides evidence for the potential correlation between neural-related transcriptome alteration and immune activity.
Persistent Identifierhttp://hdl.handle.net/10722/337589
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 0.895
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTao, ZY-
dc.contributor.authorYang, WF-
dc.contributor.authorZhu, WY-
dc.contributor.authorWang, LL-
dc.contributor.authorLi, KY-
dc.contributor.authorGuan, XY-
dc.contributor.authorSu, YX-
dc.date.accessioned2024-03-11T10:22:18Z-
dc.date.available2024-03-11T10:22:18Z-
dc.date.issued2022-11-21-
dc.identifier.citationOral Diseases, 2022-
dc.identifier.issn1354-523X-
dc.identifier.urihttp://hdl.handle.net/10722/337589-
dc.description.abstractObjectivesThis study aimed to establish a neural-related gene risk score (NRGRS) for the prediction of head and neck squamous cell carcinoma prognosis and explore its predictive value on the benefit of immune checkpoint inhibitor therapy. MethodsBased on the transcriptome data of HNSCC patients (n = 546) from The Cancer Genome Atlas database, 37 neural-related hub genes were identified by weighted gene co-expression network analysis. Four genes (ITGA5, PYGM, GNG7 and ATP2A3) were identified to construct NRGRS using Lasso-Cox regression method based on the derivation cohort and validated in the Gene Expression Omnibus cohort (n = 109). The survival analysis was performed to validate the prognostic value of NRGRS and immune characteristics in NRGRS-defined subgroups were analyzed. ResultsNRGRS-high patients had a worse overall survival than NRGRS-low patients. Tumors with high NRGRS were more likely to have high infiltration of naive CD4(+) T cells, M0, M2 macrophages and resting mast cells, which illustrated suppressive immunity and less benefit from immunotherapy therapy. ConclusionNRGRS strongly correlates with survival and is a promising biomarker to predict immunotherapy benefits for head and neck cancer patients. This study provides evidence for the potential correlation between neural-related transcriptome alteration and immune activity.-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofOral Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjecthead and neck cancer-
dc.subjectimmunotherapy-
dc.subjectnerve-cancer crosstalk-
dc.subjectoverall survival-
dc.subjectprognostic signature-
dc.titleA neural-related gene risk score for head and neck squamous cell carcinoma-
dc.typeArticle-
dc.identifier.doi10.1111/odi.14434-
dc.identifier.pmid36346196-
dc.identifier.scopuseid_2-s2.0-85142390046-
dc.identifier.eissn1601-0825-
dc.identifier.isiWOS:000888302100001-
dc.publisher.placeHOBOKEN-
dc.identifier.issnl1354-523X-

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