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- Publisher Website: 10.1016/j.freeradbiomed.2023.07.032
- Scopus: eid_2-s2.0-85166632714
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Article: Reactive nitrogen species as therapeutic targets for autophagy/mitophagy modulation to relieve neurodegeneration in multiple sclerosis: potential application for drug discovery
Title | Reactive nitrogen species as therapeutic targets for autophagy/mitophagy modulation to relieve neurodegeneration in multiple sclerosis: potential application for drug discovery |
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Authors | |
Keywords | Autophagy Mitophagy Multiple sclerosis Reactive nitrogen species Therapeutic compounds |
Issue Date | 1-Aug-2023 |
Publisher | Elsevier |
Citation | Free Radical Biology and Medicine, 2023, v. 208, p. 37-51 How to Cite? |
Abstract | Multiple sclerosis (MS) is a neuroinflammatory disease with limited therapeutic effects, eventually developing into handicap. Seeking novel therapeutic strategies for MS is timely important. Active autophagy/mitophagy could mediate neurodegeneration, while its roles in MS remain controversial. To elucidate the exact roles of autophagy/mitophagy and reveal its in-depth regulatory mechanisms, we conduct a systematic literature study and analyze the factors that might be responsible for divergent results obtained. The dynamic change levels of autophagy/mitophagy appear to be a determining factor for final neuron fate during MS pathology. Excessive neuronal autophagy/mitophagy contributes to neurodegeneration after disease onset at the active MS phase. Reactive nitrogen species (RNS) serve as key regulators for redox-related modifications and participate in autophagy/mitophagy modulation in MS. Nitric oxide (•NO) and peroxynitrite (ONOO−), two representative RNS, could nitrate or nitrosate Drp1/parkin/PINK1 pathway, activating excessive mitophagy and aggravating neuronal injury. Targeting RNS-mediated excessive autophagy/mitophagy could be a promising strategy for developing novel anti-MS drugs. In this review, we highlight the important roles of RNS-mediated autophagy/mitophagy in neuronal injury and review the potential therapeutic compounds with the bioactivities of inhibiting RNS-mediated autophagy/mitophagy activation and attenuating MS progression. Overall, we conclude that reactive nitrogen species could be promising therapeutic targets to regulate autophagy/mitophagy for multiple sclerosis treatment. |
Persistent Identifier | http://hdl.handle.net/10722/337564 |
ISSN | 2023 Impact Factor: 7.1 2023 SCImago Journal Rankings: 1.752 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li ,W | - |
dc.contributor.author | Wu, M | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Shen J | - |
dc.date.accessioned | 2024-03-11T10:21:52Z | - |
dc.date.available | 2024-03-11T10:21:52Z | - |
dc.date.issued | 2023-08-01 | - |
dc.identifier.citation | Free Radical Biology and Medicine, 2023, v. 208, p. 37-51 | - |
dc.identifier.issn | 0891-5849 | - |
dc.identifier.uri | http://hdl.handle.net/10722/337564 | - |
dc.description.abstract | <p><a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/multiple-sclerosis" title="Learn more about Multiple sclerosis from ScienceDirect's AI-generated Topic Pages">Multiple sclerosis</a> (MS) is a neuroinflammatory disease with limited therapeutic effects, eventually developing into handicap. Seeking novel therapeutic strategies for MS is timely important. Active autophagy/mitophagy could mediate <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/neurodegeneration" title="Learn more about neurodegeneration from ScienceDirect's AI-generated Topic Pages">neurodegeneration</a>, while its roles in MS remain controversial. To elucidate the exact roles of autophagy/mitophagy and reveal its in-depth regulatory mechanisms, we conduct a systematic literature study and analyze the factors that might be responsible for divergent results obtained. The dynamic change levels of autophagy/mitophagy appear to be a determining factor for final neuron fate during MS pathology. Excessive neuronal autophagy/mitophagy contributes to <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/neurodegeneration" title="Learn more about neurodegeneration from ScienceDirect's AI-generated Topic Pages">neurodegeneration</a> after disease onset at the active MS phase. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/reactive-nitrogen-species" title="Learn more about Reactive nitrogen species from ScienceDirect's AI-generated Topic Pages">Reactive nitrogen species</a> (RNS) serve as key regulators for redox-related modifications and participate in autophagy/mitophagy modulation in MS. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/nitric-oxide" title="Learn more about Nitric oxide from ScienceDirect's AI-generated Topic Pages">Nitric oxide</a> (<sup>•</sup>NO) and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/peroxynitrite" title="Learn more about peroxynitrite from ScienceDirect's AI-generated Topic Pages">peroxynitrite</a> (ONOO<sup>−</sup>), two representative RNS, could nitrate or nitrosate Drp1/parkin/PINK1 pathway, activating excessive mitophagy and aggravating neuronal injury. Targeting RNS-mediated excessive autophagy/mitophagy could be a promising strategy for developing novel anti-MS <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/chemotherapeutic-agent" title="Learn more about drugs from ScienceDirect's AI-generated Topic Pages">drugs</a>. In this review, we highlight the important roles of RNS-mediated autophagy/mitophagy in neuronal injury and review the potential therapeutic compounds with the bioactivities of inhibiting RNS-mediated autophagy/mitophagy activation and attenuating MS progression. Overall, we conclude that reactive nitrogen species could be promising therapeutic targets to regulate autophagy/mitophagy for multiple sclerosis <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/therapeutic-procedure" title="Learn more about treatment from ScienceDirect's AI-generated Topic Pages">treatment</a>.</p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Free Radical Biology and Medicine | - |
dc.subject | Autophagy | - |
dc.subject | Mitophagy | - |
dc.subject | Multiple sclerosis | - |
dc.subject | Reactive nitrogen species | - |
dc.subject | Therapeutic compounds | - |
dc.title | Reactive nitrogen species as therapeutic targets for autophagy/mitophagy modulation to relieve neurodegeneration in multiple sclerosis: potential application for drug discovery | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.freeradbiomed.2023.07.032 | - |
dc.identifier.scopus | eid_2-s2.0-85166632714 | - |
dc.identifier.volume | 208 | - |
dc.identifier.spage | 37 | - |
dc.identifier.epage | 51 | - |
dc.identifier.eissn | 1873-4596 | - |
dc.identifier.isi | WOS:001052746500001 | - |
dc.identifier.issnl | 0891-5849 | - |