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Article: Clinical Value of Computational Angiography-derived Fractional Flow Reserve in Stable Coronary Artery Disease

TitleClinical Value of Computational Angiography-derived Fractional Flow Reserve in Stable Coronary Artery Disease
Authors
KeywordsComputational pressure-flow dynamics
Coronary angiography
Coronary artery disease
Fractional flow reserve
Percutaneous coronary intervention
Issue Date29-Mar-2023
PublisherSpringer
Citation
Journal of Cardiovascular Translational Research, 2023 How to Cite?
Abstract

The utilization of FFR remains low. Our study evaluated the per-vessel prognostic value of computational pressure-flow dynamics-derived FFR (caFFR) among patients with stable coronary artery disease. A total of 3329 vessels from 1308 patients were included and analysed. They were stratified into ischaemic (caFFR ≤ 0.8) and non-ischaemic (caFFR > 0.8) cohorts, and the associations between PCI and outcomes were evaluated. The third cohort comprised all included vessels, and the associations between treatment adherent-to-caFFR (PCI in vessels with caFFR ≤ 0.8 and no PCI in vessels with caFFR > 0.8) and outcomes were evaluated. The primary outcome was VOCE, defined as a composite of vessel-related cardiovascular mortality, non-fatal myocardial infarction, and repeat revascularization. PCI was associated with a lower 3-year risk of VOCE in the ischaemic cohort (HR, 0.44; 95% CI, 0.26–0.74; P = 0.002) but not in the non-ischaemic cohort. The risk of VOCE was lower in the adherent-to-caFFR group (n = 2649) (HR, 0.69; 95% CI, 0.48–0.98; P = 0.039). Graphical Abstract: A novel index that uses coronary angiography images to estimate FFR may have substantial clinical value in guiding management among patients with stable coronary artery disease. [Figure not available: see fulltext.].


Persistent Identifierhttp://hdl.handle.net/10722/337482
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.768
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, Calvin Ka-Lam-
dc.contributor.authorLam, Lok-Yee-
dc.contributor.authorLi, Kwan-Yu-
dc.contributor.authorFeng, Yundi-
dc.contributor.authorCao, Gaozhen-
dc.contributor.authorWu, Min-
dc.contributor.authorWang, Run-
dc.contributor.authorWu, Mei-Zhen-
dc.contributor.authorRen, Qing-Wen-
dc.contributor.authorYu, Si-Yeung-
dc.contributor.authorTse, Yi-Kei-
dc.contributor.authorLi, Hang-Long-
dc.contributor.authorYu, Shuk-Yin-
dc.contributor.authorTse, Hung-Fat-
dc.contributor.authorXu, Bo-
dc.contributor.authorYiu, Kai-Hang-
dc.date.accessioned2024-03-11T10:21:13Z-
dc.date.available2024-03-11T10:21:13Z-
dc.date.issued2023-03-29-
dc.identifier.citationJournal of Cardiovascular Translational Research, 2023-
dc.identifier.issn1937-5387-
dc.identifier.urihttp://hdl.handle.net/10722/337482-
dc.description.abstract<p>The utilization of FFR remains low. Our study evaluated the per-vessel prognostic value of computational pressure-flow dynamics-derived FFR (caFFR) among patients with stable coronary artery disease. A total of 3329 vessels from 1308 patients were included and analysed. They were stratified into ischaemic (caFFR ≤ 0.8) and non-ischaemic (caFFR &gt; 0.8) cohorts, and the associations between PCI and outcomes were evaluated. The third cohort comprised all included vessels, and the associations between treatment adherent-to-caFFR (PCI in vessels with caFFR ≤ 0.8 and no PCI in vessels with caFFR &gt; 0.8) and outcomes were evaluated. The primary outcome was VOCE, defined as a composite of vessel-related cardiovascular mortality, non-fatal myocardial infarction, and repeat revascularization. PCI was associated with a lower 3-year risk of VOCE in the ischaemic cohort (HR, 0.44; 95% CI, 0.26–0.74; P = 0.002) but not in the non-ischaemic cohort. The risk of VOCE was lower in the adherent-to-caFFR group (n = 2649) (HR, 0.69; 95% CI, 0.48–0.98; P = 0.039). Graphical Abstract: A novel index that uses coronary angiography images to estimate FFR may have substantial clinical value in guiding management among patients with stable coronary artery disease. [Figure not available: see fulltext.].</p>-
dc.languageeng-
dc.publisherSpringer-
dc.relation.ispartofJournal of Cardiovascular Translational Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectComputational pressure-flow dynamics-
dc.subjectCoronary angiography-
dc.subjectCoronary artery disease-
dc.subjectFractional flow reserve-
dc.subjectPercutaneous coronary intervention-
dc.titleClinical Value of Computational Angiography-derived Fractional Flow Reserve in Stable Coronary Artery Disease-
dc.typeArticle-
dc.identifier.doi10.1007/s12265-023-10381-x-
dc.identifier.scopuseid_2-s2.0-85151289949-
dc.identifier.eissn1937-5395-
dc.identifier.isiWOS:000960613700001-
dc.identifier.issnl1937-5387-

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