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- Publisher Website: 10.3748/wjg.v27.i25.3790
- Scopus: eid_2-s2.0-85111951719
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Article: Human immune repertoire in hepatitis B virus infection
| Title | Human immune repertoire in hepatitis B virus infection |
|---|---|
| Authors | |
| Keywords | B-cell receptor Chronic viral infection Hepatitis B virus High-throughput sequencing Immune repertoire T-cell receptor |
| Issue Date | 7-Jul-2021 |
| Publisher | Baishideng Publishing Group |
| Citation | World Journal of Gastroenterology, 2021, v. 27, n. 25, p. 3790-3801 How to Cite? |
| Abstract | Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination. |
| Persistent Identifier | http://hdl.handle.net/10722/337210 |
| ISSN | 2021 Impact Factor: 5.374 2020 SCImago Journal Rankings: 1.427 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zhan, Q | - |
| dc.contributor.author | Xu, JH | - |
| dc.contributor.author | Yu, YY | - |
| dc.contributor.author | Lo, KNE | - |
| dc.contributor.author | Felicianna | - |
| dc.contributor.author | El-Nezami, H | - |
| dc.contributor.author | Zeng, Z | - |
| dc.date.accessioned | 2024-03-11T10:18:56Z | - |
| dc.date.available | 2024-03-11T10:18:56Z | - |
| dc.date.issued | 2021-07-07 | - |
| dc.identifier.citation | World Journal of Gastroenterology, 2021, v. 27, n. 25, p. 3790-3801 | - |
| dc.identifier.issn | 1007-9327 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/337210 | - |
| dc.description.abstract | <p>Hepatitis B virus (HBV) infection is a public health threat that affects 257 million people worldwide and can progress to liver cirrhosis, liver failure, and hepatocellular carcinoma. The HBV antigen- induced adaptive immune response plays an important role in HBV clearance. Immune repertoire sequencing (IRS) has been used to investigate the molecular mechanisms behind the immune system, find novel ways to treat HBV infection, and evaluate the genetic responses and immune characteristics of individuals infected by HBV or immunized by HBV vaccine. This review summarizes the human immune repertoire analysis methodology, and the application of the IRS in the prediction of HBV infection progression, treatment, and vaccination.<br></p> | - |
| dc.language | eng | - |
| dc.publisher | Baishideng Publishing Group | - |
| dc.relation.ispartof | World Journal of Gastroenterology | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.subject | B-cell receptor | - |
| dc.subject | Chronic viral infection | - |
| dc.subject | Hepatitis B virus | - |
| dc.subject | High-throughput sequencing | - |
| dc.subject | Immune repertoire | - |
| dc.subject | T-cell receptor | - |
| dc.title | Human immune repertoire in hepatitis B virus infection | - |
| dc.type | Article | - |
| dc.identifier.doi | 10.3748/wjg.v27.i25.3790 | - |
| dc.identifier.scopus | eid_2-s2.0-85111951719 | - |
| dc.identifier.volume | 27 | - |
| dc.identifier.issue | 25 | - |
| dc.identifier.spage | 3790 | - |
| dc.identifier.epage | 3801 | - |
| dc.identifier.eissn | 2219-2840 | - |
| dc.identifier.issnl | 1007-9327 | - |