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Article: A New Look at the Effects of Engineered ZnO and TiO2 Nanoparticles: Evidence from Transcriptomics Studies

TitleA New Look at the Effects of Engineered ZnO and TiO2 Nanoparticles: Evidence from Transcriptomics Studies
Authors
Keywords(eco)toxicology
animal models (in vivo)
Arabidopsis thaliana
C. elegans
cell cultures (in vitro)
engineered metal nanoparticles
titanium dioxide
transcriptomics
zebrafish
zinc oxide
Issue Date7-Apr-2022
PublisherMDPI
Citation
Nanomaterials, 2022, v. 12, n. 8 How to Cite?
AbstractTitanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) have attracted a great deal of attention due to their excellent electrical, optical, whitening, UV-adsorbing and bactericidal properties. The extensive production and utilization of these NPs increases their chances of being released into the environment and conferring unintended biological effects upon exposure. With the increasingly prevalent use of the omics technique, new data are burgeoning which provide a global view on the overall changes induced by exposures to NPs. In this review, we provide an account of the biological effects of ZnO and TiO2 NPs arising from transcriptomics in in vivo and in vitro studies. In addition to studies on humans and mice, we also describe findings on ecotoxicology-related species, such as Danio rerio (zebrafish), Caenorhabditis elegans (nematode) or Arabidopsis thaliana (thale cress). Based on evidence from transcriptomics studies, we discuss particle-induced biological effects, including cytotoxicity, developmental alterations and immune responses, that are dependent on both material-intrinsic and acquired/transformed properties. This review seeks to provide a holistic insight into the global changes induced by ZnO and TiO2 NPs pertinent to human and ecotoxicology.
Persistent Identifierhttp://hdl.handle.net/10722/337200
ISSN
2023 Impact Factor: 4.4
2023 SCImago Journal Rankings: 0.798
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, S-
dc.contributor.authorAlenius, H-
dc.contributor.authorEl-Nezami, H-
dc.contributor.authorKarisola, P-
dc.date.accessioned2024-03-11T10:18:51Z-
dc.date.available2024-03-11T10:18:51Z-
dc.date.issued2022-04-07-
dc.identifier.citationNanomaterials, 2022, v. 12, n. 8-
dc.identifier.issn2079-4991-
dc.identifier.urihttp://hdl.handle.net/10722/337200-
dc.description.abstractTitanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles (NPs) have attracted a great deal of attention due to their excellent electrical, optical, whitening, UV-adsorbing and bactericidal properties. The extensive production and utilization of these NPs increases their chances of being released into the environment and conferring unintended biological effects upon exposure. With the increasingly prevalent use of the omics technique, new data are burgeoning which provide a global view on the overall changes induced by exposures to NPs. In this review, we provide an account of the biological effects of ZnO and TiO2 NPs arising from transcriptomics in in vivo and in vitro studies. In addition to studies on humans and mice, we also describe findings on ecotoxicology-related species, such as Danio rerio (zebrafish), Caenorhabditis elegans (nematode) or Arabidopsis thaliana (thale cress). Based on evidence from transcriptomics studies, we discuss particle-induced biological effects, including cytotoxicity, developmental alterations and immune responses, that are dependent on both material-intrinsic and acquired/transformed properties. This review seeks to provide a holistic insight into the global changes induced by ZnO and TiO2 NPs pertinent to human and ecotoxicology.-
dc.languageeng-
dc.publisherMDPI-
dc.relation.ispartofNanomaterials-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subject(eco)toxicology-
dc.subjectanimal models (in vivo)-
dc.subjectArabidopsis thaliana-
dc.subjectC. elegans-
dc.subjectcell cultures (in vitro)-
dc.subjectengineered metal nanoparticles-
dc.subjecttitanium dioxide-
dc.subjecttranscriptomics-
dc.subjectzebrafish-
dc.subjectzinc oxide-
dc.titleA New Look at the Effects of Engineered ZnO and TiO2 Nanoparticles: Evidence from Transcriptomics Studies-
dc.typeArticle-
dc.identifier.doi10.3390/nano12081247-
dc.identifier.scopuseid_2-s2.0-85127660035-
dc.identifier.volume12-
dc.identifier.issue8-
dc.identifier.eissn2079-4991-
dc.identifier.isiWOS:000786888100001-
dc.identifier.issnl2079-4991-

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