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Article: Altered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori

TitleAltered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori
Authors
Issue Date17-Apr-2023
PublisherNature Research
Citation
Nature Communications, 2023, v. 14, n. 1 How to Cite?
Abstract

Transient gut microbiota alterations have been reported after antibiotic therapy for Helicobacter pylori. However, alteration in the gut virome after H. pylori eradication remains uncertain. Here, we apply metagenomic sequencing to fecal samples of 44 H. pylori-infected patients at baseline, 6-week (N = 44), and 6-month (N = 33) after treatment. Following H. pylori eradication, we discover contraction of the gut virome diversity, separation of virome community with increased community difference, and shifting towards a higher proportion of core virus. While the gut microbiota is altered at 6-week and restored at 6-month, the virome community shows contraction till 6-month after the treatment with enhanced phage-bacteria interactions at 6-week. Multiple courses of antibiotic treatments further lead to lower virus community diversity when compared with treatment naive patients. Our results demonstrate that H. pylori eradication therapies not only result in transient alteration in gut microbiota but also significantly alter the previously less known gut virome community.


Persistent Identifierhttp://hdl.handle.net/10722/337007
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Lingling-
dc.contributor.authorYao, Haobin-
dc.contributor.authorMorgan, Daniel-
dc.contributor.authorLau, Kam Shing-
dc.contributor.authorLeung, Suet Yi-
dc.contributor.authorHo, Joshua-
dc.contributor.authorLeung, Wai Keung-
dc.date.accessioned2024-03-11T10:17:19Z-
dc.date.available2024-03-11T10:17:19Z-
dc.date.issued2023-04-17-
dc.identifier.citationNature Communications, 2023, v. 14, n. 1-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/337007-
dc.description.abstract<p>Transient gut microbiota alterations have been reported after antibiotic therapy for <em>Helicobacter pylori</em>. However, alteration in the gut virome after <em>H. pylori</em> eradication remains uncertain. Here, we apply metagenomic sequencing to fecal samples of 44 <em>H. pylori</em>-infected patients at baseline, 6-week (<em>N</em> = 44), and 6-month (<em>N</em> = 33) after treatment. Following <em>H. pylori</em> eradication, we discover contraction of the gut virome diversity, separation of virome community with increased community difference, and shifting towards a higher proportion of core virus. While the gut microbiota is altered at 6-week and restored at 6-month, the virome community shows contraction till 6-month after the treatment with enhanced phage-bacteria interactions at 6-week. Multiple courses of antibiotic treatments further lead to lower virus community diversity when compared with treatment naive patients. Our results demonstrate that <em>H. pylori</em> eradication therapies not only result in transient alteration in gut microbiota but also significantly alter the previously less known gut virome community.</p>-
dc.languageeng-
dc.publisherNature Research-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleAltered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori-
dc.typeArticle-
dc.identifier.doi10.1038/s41467-023-37975-y-
dc.identifier.scopuseid_2-s2.0-85152649412-
dc.identifier.volume14-
dc.identifier.issue1-
dc.identifier.eissn2041-1723-
dc.identifier.isiWOS:001013529900009-
dc.identifier.issnl2041-1723-

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