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Article: Infection-prevention on Ti implants by controlled drug release from folic acid/ZnO quantum dots sealed titania nanotubes

TitleInfection-prevention on Ti implants by controlled drug release from folic acid/ZnO quantum dots sealed titania nanotubes
Authors
KeywordsAntibacterial
Drug delivery
Infection prevention
pH sensitivity
Quantum dots
ZnO
Issue Date4-Jan-2018
PublisherElsevier
Citation
Materials Science and Engineering: C, 2018, v. 85, p. 214-224 How to Cite?
AbstractBacterial infections and related complications are predominantly responsible for the failure of artificial biomaterials assisted tissue regeneration in clinic. In this work, a hybrid surface system is applied to prolong the drug release duration from dug-loaded titania nanotubes and thus to prevent Ti implants-associated bacterial infections. This feature is endowed by conjugating folic acid (FA) onto the surface of ZnO quantum dots (QDs)-NH2 via an amidation reaction. Titania nanotubes (TNTs) loaded with vancomycin (Van) are capped by these FA functionalized ZnO (ZnO-FA) QDs that keep stable in normal physiological environments but dissolves to Zn2 + in the mildly acidic environment after bacterial infections as validated by the drug release profile. The antibacterial ratio of TNTs-Van@ZnO-FA QDs against Staphylococcus aureus is enhanced from 60.8% to 98.8%while this value is only increased from 85.2% to 95.1% for TNTs-Van once the pH value of the environment is decreased from 7.4 to 5.5. This is due to the synergistic effects of Van and Zn2 + because the gradual dissolution of ZnO-FA caps on TNTs with the decrease of pH value can induce the acceleration of both Van and Zn2 + release. In addition, this TNTs-Van@ZnO-FA system also exhibits excellent biocompatibility because of the folic acid and sustained release of Zn ions. Hence, this surface system can be potentially used as a promising bioplatform on Ti-based metallic implants to prevent bacterial infection with a long-lasting effect.
Persistent Identifierhttp://hdl.handle.net/10722/336991
ISSN
2023 Impact Factor: 8.1
2020 SCImago Journal Rankings: 1.234
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiang, YM-
dc.contributor.authorLiu, XM-
dc.contributor.authorMao, CY-
dc.contributor.authorLiu, XM-
dc.contributor.authorCui, ZD-
dc.contributor.authorYang, XJ-
dc.contributor.authorYeung, KWK-
dc.contributor.authorZheng, YF-
dc.contributor.authorWu, SL -
dc.date.accessioned2024-03-11T10:17:10Z-
dc.date.available2024-03-11T10:17:10Z-
dc.date.issued2018-01-04-
dc.identifier.citationMaterials Science and Engineering: C, 2018, v. 85, p. 214-224-
dc.identifier.issn0928-4931-
dc.identifier.urihttp://hdl.handle.net/10722/336991-
dc.description.abstractBacterial infections and related complications are predominantly responsible for the failure of artificial biomaterials assisted tissue regeneration in clinic. In this work, a hybrid surface system is applied to prolong the drug release duration from dug-loaded titania nanotubes and thus to prevent Ti implants-associated bacterial infections. This feature is endowed by conjugating folic acid (FA) onto the surface of ZnO quantum dots (QDs)-NH2 via an amidation reaction. Titania nanotubes (TNTs) loaded with vancomycin (Van) are capped by these FA functionalized ZnO (ZnO-FA) QDs that keep stable in normal physiological environments but dissolves to Zn2 + in the mildly acidic environment after bacterial infections as validated by the drug release profile. The antibacterial ratio of TNTs-Van@ZnO-FA QDs against Staphylococcus aureus is enhanced from 60.8% to 98.8%while this value is only increased from 85.2% to 95.1% for TNTs-Van once the pH value of the environment is decreased from 7.4 to 5.5. This is due to the synergistic effects of Van and Zn2 + because the gradual dissolution of ZnO-FA caps on TNTs with the decrease of pH value can induce the acceleration of both Van and Zn2 + release. In addition, this TNTs-Van@ZnO-FA system also exhibits excellent biocompatibility because of the folic acid and sustained release of Zn ions. Hence, this surface system can be potentially used as a promising bioplatform on Ti-based metallic implants to prevent bacterial infection with a long-lasting effect.-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofMaterials Science and Engineering: C-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAntibacterial-
dc.subjectDrug delivery-
dc.subjectInfection prevention-
dc.subjectpH sensitivity-
dc.subjectQuantum dots-
dc.subjectZnO-
dc.titleInfection-prevention on Ti implants by controlled drug release from folic acid/ZnO quantum dots sealed titania nanotubes-
dc.typeArticle-
dc.identifier.doi10.1016/j.msec.2017.12.034-
dc.identifier.scopuseid_2-s2.0-85040050401-
dc.identifier.volume85-
dc.identifier.spage214-
dc.identifier.epage224-
dc.identifier.eissn1873-0191-
dc.identifier.isiWOS:000428496400023-
dc.identifier.issnl0928-4931-

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