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Article: Highly Effective and Noninvasive Near-Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min

TitleHighly Effective and Noninvasive Near-Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min
Authors
Keywordsantibacterial
biofilms
IR780
MoS2
phototherapy
Issue Date19-Jul-2019
PublisherWiley Open Access
Citation
Advanced Science, 2019, v. 6, n. 17 How to Cite?
AbstractBiofilms have been related to the persistence of infections on medical implants, and these cannot be eradicated because of the resistance of biofilm structures. Therefore, a biocompatible phototherapeutic system is developed composed of MoS2, IR780 photosensitizer, and arginine–glycine–aspartic acid–cysteine (RGDC) to safely eradicate biofilms on titanium implants within 20 min. The magnetron-sputtered MoS2 film possesses excellent photothermal properties, and IR780 can produce reactive oxygen species (ROS) with the irradiation of near-infrared (NIR, λ = 700–1100 nm) light. Consequently, the combination of photothermal therapy (PTT) and photodynamic therapy (PDT), assisted by glutathione oxidation accelerated by NIR light, can provide synergistic and rapid killing of bacteria, i.e., 98.99 ± 0.42% eradication ratio against a Staphylococcus aureus biofilm in vivo within 20 min, which is much greater than that of PTT or PDT alone. With the assistance of ROS, the permeability of damaged bacterial membranes increases, and the damaged bacterial membranes become more sensitive to heat, thus accelerating the leakage of proteins from the bacteria. In addition, RGDC can provide excellent biosafety and osteoconductivity, which is confirmed by in vivo animal experiments.
Persistent Identifierhttp://hdl.handle.net/10722/336990
ISSN
2023 Impact Factor: 14.3
2023 SCImago Journal Rankings: 3.914
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, M-
dc.contributor.authorLi, LQ-
dc.contributor.authorSu, K-
dc.contributor.authorLiu, XM-
dc.contributor.authorZhang, TJ-
dc.contributor.authorLiang, YQ-
dc.contributor.authorJing, DD-
dc.contributor.authorYang, XJ-
dc.contributor.authorZheng, D-
dc.contributor.authorCui, ZD-
dc.contributor.authorLi, ZY-
dc.contributor.authorZhu, SL-
dc.contributor.authorYeung, KWK-
dc.contributor.authorZheng, YF-
dc.contributor.authorWang, XB-
dc.contributor.authorWu, SL -
dc.date.accessioned2024-03-11T10:17:09Z-
dc.date.available2024-03-11T10:17:09Z-
dc.date.issued2019-07-19-
dc.identifier.citationAdvanced Science, 2019, v. 6, n. 17-
dc.identifier.issn2198-3844-
dc.identifier.urihttp://hdl.handle.net/10722/336990-
dc.description.abstractBiofilms have been related to the persistence of infections on medical implants, and these cannot be eradicated because of the resistance of biofilm structures. Therefore, a biocompatible phototherapeutic system is developed composed of MoS2, IR780 photosensitizer, and arginine–glycine–aspartic acid–cysteine (RGDC) to safely eradicate biofilms on titanium implants within 20 min. The magnetron-sputtered MoS2 film possesses excellent photothermal properties, and IR780 can produce reactive oxygen species (ROS) with the irradiation of near-infrared (NIR, λ = 700–1100 nm) light. Consequently, the combination of photothermal therapy (PTT) and photodynamic therapy (PDT), assisted by glutathione oxidation accelerated by NIR light, can provide synergistic and rapid killing of bacteria, i.e., 98.99 ± 0.42% eradication ratio against a Staphylococcus aureus biofilm in vivo within 20 min, which is much greater than that of PTT or PDT alone. With the assistance of ROS, the permeability of damaged bacterial membranes increases, and the damaged bacterial membranes become more sensitive to heat, thus accelerating the leakage of proteins from the bacteria. In addition, RGDC can provide excellent biosafety and osteoconductivity, which is confirmed by in vivo animal experiments.-
dc.languageeng-
dc.publisherWiley Open Access-
dc.relation.ispartofAdvanced Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectantibacterial-
dc.subjectbiofilms-
dc.subjectIR780-
dc.subjectMoS2-
dc.subjectphototherapy-
dc.titleHighly Effective and Noninvasive Near-Infrared Eradication of a Staphylococcus aureus Biofilm on Implants by a Photoresponsive Coating within 20 Min-
dc.typeArticle-
dc.identifier.doi10.1002/advs.201900599-
dc.identifier.scopuseid_2-s2.0-85069871673-
dc.identifier.volume6-
dc.identifier.issue17-
dc.identifier.eissn2198-3844-
dc.identifier.isiWOS:000476527600001-
dc.identifier.issnl2198-3844-

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