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Article: Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria

TitleMicrowave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria
Authors
Issue Date5-May-2022
PublisherNature Research
Citation
Nature Communications, 2022, v. 13, n. 1 How to Cite?
AbstractOwing to the existence of the outer membrane barrier, most antibacterial agents cannot penetrate Gram-negative bacteria and are ineffective. Here, we report a general method for narrow-spectrum antibacterial Garcinia nanoparticles that can only be effective to kill Gram-positive bacteria, to effectively eliminate Gram-negative bacteria by creating transient nanopores in bacterial outer membrane to induce drug entry under microwaves assistance. In vitro, under 15 min of microwaves irradiation, the antibacterial efficiency of Garcinia nanoparticles against Escherichia coli can be enhanced from 6.73% to 99.48%. In vivo, MV-assisted GNs can effectively cure mice with bacterial pneumonia. The combination of molecular dynamics simulation and experimental results reveal that the robust anti-E. coli effectiveness of Garcinia nanoparticles is attributed to the synergy of Garcinia nanoparticles and microwaves. This work presents a strategy for effectively treating both Gram-negative and Gram-positive bacteria co-infected pneumonia using herbal medicine nanoparticles with MV assistance as an exogenous antibacterial auxiliary.
Persistent Identifierhttp://hdl.handle.net/10722/336989
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorQiao, YQ-
dc.contributor.authorXu, YD-
dc.contributor.authorLiu, XM-
dc.contributor.authorZheng, YF-
dc.contributor.authorLi, B-
dc.contributor.authorHan, Y-
dc.contributor.authorLi, ZY-
dc.contributor.authorYeung, KWK-
dc.contributor.authorLiang, YQ-
dc.contributor.authorZhu, SL-
dc.contributor.authorCui, ZD-
dc.contributor.authorWu, SL -
dc.date.accessioned2024-03-11T10:17:09Z-
dc.date.available2024-03-11T10:17:09Z-
dc.date.issued2022-05-05-
dc.identifier.citationNature Communications, 2022, v. 13, n. 1-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/336989-
dc.description.abstractOwing to the existence of the outer membrane barrier, most antibacterial agents cannot penetrate Gram-negative bacteria and are ineffective. Here, we report a general method for narrow-spectrum antibacterial Garcinia nanoparticles that can only be effective to kill Gram-positive bacteria, to effectively eliminate Gram-negative bacteria by creating transient nanopores in bacterial outer membrane to induce drug entry under microwaves assistance. In vitro, under 15 min of microwaves irradiation, the antibacterial efficiency of Garcinia nanoparticles against Escherichia coli can be enhanced from 6.73% to 99.48%. In vivo, MV-assisted GNs can effectively cure mice with bacterial pneumonia. The combination of molecular dynamics simulation and experimental results reveal that the robust anti-E. coli effectiveness of Garcinia nanoparticles is attributed to the synergy of Garcinia nanoparticles and microwaves. This work presents a strategy for effectively treating both Gram-negative and Gram-positive bacteria co-infected pneumonia using herbal medicine nanoparticles with MV assistance as an exogenous antibacterial auxiliary.-
dc.languageeng-
dc.publisherNature Research-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleMicrowave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria-
dc.typeArticle-
dc.identifier.doi10.1038/s41467-022-30125-w-
dc.identifier.scopuseid_2-s2.0-85129360885-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.eissn2041-1723-
dc.identifier.isiWOS:000791508600013-
dc.identifier.issnl2041-1723-

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