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Article: In vitro and in vivo studies on pure Mg, Mg-1Ca and Mg-2Sr alloys processed by equal channel angular pressing

TitleIn vitro and in vivo studies on pure Mg, Mg-1Ca and Mg-2Sr alloys processed by equal channel angular pressing
Authors
KeywordsBiocompatibility
Degradation behavior
Equal channel angular pressing
Magnesium alloys
Mechanical property
Issue Date24-Mar-2020
PublisherChongqing University
Citation
Nano Materials Science, 2020, v. 2, n. 1, p. 96-108 How to Cite?
AbstractIn the present work, the biomedical as-cast pure Mg, Mg–1Ca and Mg–2Sr alloys were processed with equal channel angular pressing (ECAP) technique to develop ultrafine microstructure within the materials, and their microstructures, mechanical properties, degradation behavior, cytocompatibility in vitro and biocompatibility in vivo were studied comprehensively. Finer-gained microstructures and improved mechanical properties of these three materials after ECAP were confirmed compared to their as-cast counterparts. Moreover, after ECAP the degradation rate of pure Mg was increased while that of Mg–1Ca or Mg–2Sr alloys decreased compared to the as-cast counterparts. Additionally, good in vitro cytocompatibility and in vivo biocompatibility of these three materials were revealed by cell cultural tests using osteoblastic MC3T3-E1 and human mesenchymal stem cells (hMSC) and in vivo animal tests at the lateral epicondyle of SD-rats’ femur. This study offers an alternative powerful avenue to achieve good comprehensive properties of magnesium-based biodegradable metals. It might also help to extend the applied range of magnesium-based biodegradable metals in orthopedic field.
Persistent Identifierhttp://hdl.handle.net/10722/336985
ISSN
2023 Impact Factor: 12.6
2023 SCImago Journal Rankings: 1.721
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, WT-
dc.contributor.authorShen, YN-
dc.contributor.authorShen, J-
dc.contributor.authorShen, DN-
dc.contributor.authorLiu, X-
dc.contributor.authorZheng, YF-
dc.contributor.authorYeung, KWK-
dc.contributor.authorGuan, SK-
dc.contributor.authorKulyasova, OB-
dc.contributor.authorValiev, RZ -
dc.date.accessioned2024-03-11T10:17:07Z-
dc.date.available2024-03-11T10:17:07Z-
dc.date.issued2020-03-24-
dc.identifier.citationNano Materials Science, 2020, v. 2, n. 1, p. 96-108-
dc.identifier.issn2096-6482-
dc.identifier.urihttp://hdl.handle.net/10722/336985-
dc.description.abstractIn the present work, the biomedical as-cast pure Mg, Mg–1Ca and Mg–2Sr alloys were processed with equal channel angular pressing (ECAP) technique to develop ultrafine microstructure within the materials, and their microstructures, mechanical properties, degradation behavior, cytocompatibility in vitro and biocompatibility in vivo were studied comprehensively. Finer-gained microstructures and improved mechanical properties of these three materials after ECAP were confirmed compared to their as-cast counterparts. Moreover, after ECAP the degradation rate of pure Mg was increased while that of Mg–1Ca or Mg–2Sr alloys decreased compared to the as-cast counterparts. Additionally, good in vitro cytocompatibility and in vivo biocompatibility of these three materials were revealed by cell cultural tests using osteoblastic MC3T3-E1 and human mesenchymal stem cells (hMSC) and in vivo animal tests at the lateral epicondyle of SD-rats’ femur. This study offers an alternative powerful avenue to achieve good comprehensive properties of magnesium-based biodegradable metals. It might also help to extend the applied range of magnesium-based biodegradable metals in orthopedic field.-
dc.languageeng-
dc.publisherChongqing University-
dc.relation.ispartofNano Materials Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectBiocompatibility-
dc.subjectDegradation behavior-
dc.subjectEqual channel angular pressing-
dc.subjectMagnesium alloys-
dc.subjectMechanical property-
dc.titleIn vitro and in vivo studies on pure Mg, Mg-1Ca and Mg-2Sr alloys processed by equal channel angular pressing-
dc.typeArticle-
dc.identifier.doi10.1016/j.nanoms.2020.03.004-
dc.identifier.scopuseid_2-s2.0-85090213560-
dc.identifier.volume2-
dc.identifier.issue1-
dc.identifier.spage96-
dc.identifier.epage108-
dc.identifier.eissn2589-9651-
dc.identifier.isiWOS:000925206600001-
dc.identifier.issnl2589-9651-

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