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Article: Association Between Visit-to-Visit Lipid Variability and Incident Cancer: A Population-based Cohort Study

TitleAssociation Between Visit-to-Visit Lipid Variability and Incident Cancer: A Population-based Cohort Study
Authors
Issue Date2023
Citation
Current Problems in Cardiology, 2023, v. 48, n. 1, article no. 101421 How to Cite?
AbstractDyslipidemia is associated with increased cancer risk. However, the prognostic value of visit-to-visit lipid variability (VVLV) is unexplored in this regard. To investigate the associations between the VVLV and the risk of incident cancer, we conducted a retrospective cohort study on adult patients attending a family medicine clinic in Hong Kong during 2000-2003, excluding those with <3 tests for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and total cholesterol (TC) each, those with prior cancer diagnosis, and those with <1 year of follow-up. Visit-to-visit LDL-C, HDL-C, TC, and triglycerides variabilities were measured by the coefficient of variation (CV). Patients were followed up until 31st December 2019 for the primary outcome of incident cancer. Altogether, 69,186 patients were included (26,679 males (38.6%); mean age 60 ± 13 years; mean follow-up 16 ± 3 years); 7958 patients (11.5%) had incident cancer. Higher variability of LDL-C, HDL-C, TC, and TG was associated with higher risk of incident cancer. Patients in the third tercile of the CV of LDL-C (adjusted hazard ratio (aHR) against first tercile 1.06 [1.00, 1.12], P = 0.049), HDL-C (aHR 1.37 [1.29, 1.44], P< 0.001), TC (aHR 1.10 [1.04, 1.17], P = 0.001), and TG (aHR 1.11 [1.06, 1.18], P < 0.001) had the highest risks of incident cancer. Among these, only HDL-C variability remained associated with the risk of incident cancer in users of statins/fibrates. To conclude, higher VVLV was associated with significantly higher long-term risks of incident cancer. VVLV may be a clinically useful tool for cancer risk stratification.
Persistent Identifierhttp://hdl.handle.net/10722/336883
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.934
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Jeffrey Shi Kai-
dc.contributor.authorSatti, Danish Iltaf-
dc.contributor.authorLee, Yan Hiu Athena-
dc.contributor.authorBin Waleed, Khalid-
dc.contributor.authorTang, Pias-
dc.contributor.authorMahalwar, Gauranga-
dc.contributor.authorMinhas, Abdul Mannan Khan-
dc.contributor.authorRoever, Leonardo-
dc.contributor.authorBiondi-Zoccai, Giuseppe-
dc.contributor.authorLeung, Fung Ping-
dc.contributor.authorWong, Wing Tak-
dc.contributor.authorLiu, Tong-
dc.contributor.authorZhou, Jiandong-
dc.contributor.authorTse, Gary-
dc.date.accessioned2024-02-29T06:57:12Z-
dc.date.available2024-02-29T06:57:12Z-
dc.date.issued2023-
dc.identifier.citationCurrent Problems in Cardiology, 2023, v. 48, n. 1, article no. 101421-
dc.identifier.issn0146-2806-
dc.identifier.urihttp://hdl.handle.net/10722/336883-
dc.description.abstractDyslipidemia is associated with increased cancer risk. However, the prognostic value of visit-to-visit lipid variability (VVLV) is unexplored in this regard. To investigate the associations between the VVLV and the risk of incident cancer, we conducted a retrospective cohort study on adult patients attending a family medicine clinic in Hong Kong during 2000-2003, excluding those with <3 tests for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and total cholesterol (TC) each, those with prior cancer diagnosis, and those with <1 year of follow-up. Visit-to-visit LDL-C, HDL-C, TC, and triglycerides variabilities were measured by the coefficient of variation (CV). Patients were followed up until 31st December 2019 for the primary outcome of incident cancer. Altogether, 69,186 patients were included (26,679 males (38.6%); mean age 60 ± 13 years; mean follow-up 16 ± 3 years); 7958 patients (11.5%) had incident cancer. Higher variability of LDL-C, HDL-C, TC, and TG was associated with higher risk of incident cancer. Patients in the third tercile of the CV of LDL-C (adjusted hazard ratio (aHR) against first tercile 1.06 [1.00, 1.12], P = 0.049), HDL-C (aHR 1.37 [1.29, 1.44], P< 0.001), TC (aHR 1.10 [1.04, 1.17], P = 0.001), and TG (aHR 1.11 [1.06, 1.18], P < 0.001) had the highest risks of incident cancer. Among these, only HDL-C variability remained associated with the risk of incident cancer in users of statins/fibrates. To conclude, higher VVLV was associated with significantly higher long-term risks of incident cancer. VVLV may be a clinically useful tool for cancer risk stratification.-
dc.languageeng-
dc.relation.ispartofCurrent Problems in Cardiology-
dc.titleAssociation Between Visit-to-Visit Lipid Variability and Incident Cancer: A Population-based Cohort Study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cpcardiol.2022.101421-
dc.identifier.pmid36167221-
dc.identifier.scopuseid_2-s2.0-85141286246-
dc.identifier.volume48-
dc.identifier.issue1-
dc.identifier.spagearticle no. 101421-
dc.identifier.epagearticle no. 101421-
dc.identifier.eissn1535-6280-
dc.identifier.isiWOS:000892255100013-

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