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- Publisher Website: 10.1039/c6ra12189f
- Scopus: eid_2-s2.0-84979609820
- WOS: WOS:000380353600003
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Article: Assessment on the antibacterial actIVity of nanosized silica derIVed from hypercoordinated silicon(IV) precursors
Title | Assessment on the antibacterial actIVity of nanosized silica derIVed from hypercoordinated silicon(IV) precursors |
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Authors | |
Issue Date | 2016 |
Citation | RSC Advances, 2016, v. 6, n. 71, p. 66394-66406 How to Cite? |
Abstract | Silica nanoparticles were synthesized through a versatile sol-gel combustion method from hydrazide based hypercoordinated silicon complexes derived from the reaction of silicon tetrachloride with O-silylated hydrazide derivatives. The complexes were characterized by 1H, 13C, 29Si NMR and ESI-mass spectrometric techniques. A refined morphology was observed in the product after sintering i.e. from spherical to rod shaped nanoparticles. The powder X-ray diffraction patterns and the TEM images of silica show the formation of silica nanoparticles. The IR spectra show Si-O linkages and DLS studies indicate the particle size distribution to be between 20 and 100 nm for the material before sintering and 70-120 nm after sintering at 1000 °C. A TEM image of the decomposed gel indicates the formation of crystalline silica rods. This work also demonstrates the influence of nano-sized silica particles on antibacterial activity (DIZ, MIC and MBC) i.e. better activity was shown for nano-rods derived from the hypercoordinated silicon complexes than the conventional TEOS (sol-gel) method. Experiments on the generation of reactive oxygen species (ROS) through oxidative stress demonstrate the toxicity of nanosilica particles. |
Persistent Identifier | http://hdl.handle.net/10722/336687 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Janardan, Sannapaneni | - |
dc.contributor.author | Suman, Pothini | - |
dc.contributor.author | Ragul, G. | - |
dc.contributor.author | Anjaneyulu, U. | - |
dc.contributor.author | Shivendu, R. | - |
dc.contributor.author | Dasgupta, Nandita | - |
dc.contributor.author | Ramalingam, Chidambaram | - |
dc.contributor.author | Swamiappan, Sasikumar | - |
dc.contributor.author | Vijayakrishna, Kari | - |
dc.contributor.author | Sivaramakrishna, Akella | - |
dc.date.accessioned | 2024-02-29T06:55:49Z | - |
dc.date.available | 2024-02-29T06:55:49Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | RSC Advances, 2016, v. 6, n. 71, p. 66394-66406 | - |
dc.identifier.uri | http://hdl.handle.net/10722/336687 | - |
dc.description.abstract | Silica nanoparticles were synthesized through a versatile sol-gel combustion method from hydrazide based hypercoordinated silicon complexes derived from the reaction of silicon tetrachloride with O-silylated hydrazide derivatives. The complexes were characterized by 1H, 13C, 29Si NMR and ESI-mass spectrometric techniques. A refined morphology was observed in the product after sintering i.e. from spherical to rod shaped nanoparticles. The powder X-ray diffraction patterns and the TEM images of silica show the formation of silica nanoparticles. The IR spectra show Si-O linkages and DLS studies indicate the particle size distribution to be between 20 and 100 nm for the material before sintering and 70-120 nm after sintering at 1000 °C. A TEM image of the decomposed gel indicates the formation of crystalline silica rods. This work also demonstrates the influence of nano-sized silica particles on antibacterial activity (DIZ, MIC and MBC) i.e. better activity was shown for nano-rods derived from the hypercoordinated silicon complexes than the conventional TEOS (sol-gel) method. Experiments on the generation of reactive oxygen species (ROS) through oxidative stress demonstrate the toxicity of nanosilica particles. | - |
dc.language | eng | - |
dc.relation.ispartof | RSC Advances | - |
dc.title | Assessment on the antibacterial actIVity of nanosized silica derIVed from hypercoordinated silicon(IV) precursors | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/c6ra12189f | - |
dc.identifier.scopus | eid_2-s2.0-84979609820 | - |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 71 | - |
dc.identifier.spage | 66394 | - |
dc.identifier.epage | 66406 | - |
dc.identifier.eissn | 2046-2069 | - |
dc.identifier.isi | WOS:000380353600003 | - |