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Article: Pregnancy-related breast cancer: 14-year experience in a tertiary institution in Hong Kong
Title | Pregnancy-related breast cancer: 14-year experience in a tertiary institution in Hong Kong |
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Authors | |
Issue Date | 20-Dec-2023 |
Citation | Cancer Treatment and Research Communications, 2023 How to Cite? |
Abstract | BACKGROUNDThe incidence of pregnancy-associated breast cancer (PABC) is increasing. Its tumor characteristics and overall survival compared with those in nonpregnant patients remain controversial. While there have been suggestions that PABC patients have a 40% increase in the risk of death compared to non-pregnant patients, other studies suggested similar disease outcomes. This study aims to review our local experience with PABC. METHODSTwenty-eight patients diagnosed with PABC and twenty-eight patients diagnosed at premenopausal age randomly selected by a computer-generated system during the same period were recruited. Background characteristics, tumor features, and survival were compared. RESULTSAmong the twenty-eight pregnant patients, seventeen were diagnosed during pregnancy, and eleven were diagnosed in the postpartum period. Compared to the non-pregnant breast cancer patients, they presented with less progesterone receptor-positive tumor (35.7% vs. 64.2%, p=0.03). Although there was no statistically significant difference in tumor size (p=0.44) and nodal status (p=0.16), the tumor tended to be larger in size (2.94 +/- 1.82 vs 2.40 +/- 1.69cm) and with more nodal involvement (35.7% vs 25.0%). There was also a trend of delayed presentation to medical attention, with a mean duration of 13.1 weeks in the PABC group and 8.6 weeks in the control group. However, the overall survival did not differ (p=0.63). CONCLUSIONPABC is increasing in incidence. They tend to have more aggressive features, but overall survival remains similar. A multidisciplinary approach is beneficial for providing the most appropriate care. |
Persistent Identifier | http://hdl.handle.net/10722/336431 |
ISSN | 2023 SCImago Journal Rankings: 0.793 |
DC Field | Value | Language |
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dc.contributor.author | CHEUNG, Billy Ho Hung | - |
dc.contributor.author | MAN, Vivian Chi Mei | - |
dc.contributor.author | SHAM, Goby Tze Wa | - |
dc.contributor.author | CHOW, Lorraine | - |
dc.contributor.author | CO, Michael | - |
dc.contributor.author | KWONG, Ava | - |
dc.date.accessioned | 2024-01-30T06:33:08Z | - |
dc.date.available | 2024-01-30T06:33:08Z | - |
dc.date.issued | 2023-12-20 | - |
dc.identifier.citation | Cancer Treatment and Research Communications, 2023 | - |
dc.identifier.issn | 2468-2942 | - |
dc.identifier.uri | http://hdl.handle.net/10722/336431 | - |
dc.description.abstract | <h3>BACKGROUND</h3><p>The incidence of pregnancy-associated breast cancer (PABC) is increasing. Its tumor characteristics and overall survival compared with those in nonpregnant patients remain controversial. While there have been suggestions that PABC patients have a 40% increase in the risk of death compared to non-pregnant patients, other studies suggested similar disease outcomes. This study aims to review our local experience with PABC.</p><h3>METHODS</h3><p>Twenty-eight patients diagnosed with PABC and twenty-eight patients diagnosed at premenopausal age randomly selected by a computer-generated system during the same period were recruited. Background characteristics, tumor features, and survival were compared.</p><h3>RESULTS</h3><p>Among the twenty-eight pregnant patients, seventeen were diagnosed during pregnancy, and eleven were diagnosed in the postpartum period. Compared to the non-pregnant breast cancer patients, they presented with less progesterone receptor-positive tumor (35.7% vs. 64.2%, p=0.03). Although there was no statistically significant difference in tumor size (p=0.44) and nodal status (p=0.16), the tumor tended to be larger in size (2.94 +/- 1.82 vs 2.40 +/- 1.69cm) and with more nodal involvement (35.7% vs 25.0%). There was also a trend of delayed presentation to medical attention, with a mean duration of 13.1 weeks in the PABC group and 8.6 weeks in the control group. However, the overall survival did not differ (p=0.63).</p><h3>CONCLUSION</h3><p>PABC is increasing in incidence. They tend to have more aggressive features, but overall survival remains similar. A multidisciplinary approach is beneficial for providing the most appropriate care.</p> | - |
dc.language | eng | - |
dc.relation.ispartof | Cancer Treatment and Research Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Pregnancy-related breast cancer: 14-year experience in a tertiary institution in Hong Kong | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ctarc.2023.100783 | - |
dc.identifier.issnl | 2468-2942 | - |