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- Publisher Website: 10.1109/ICCD.2015.7357107
- Scopus: eid_2-s2.0-84962460161
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Conference Paper: Cyber-physical integration in programmable microfluidic biochips
Title | Cyber-physical integration in programmable microfluidic biochips |
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Authors | |
Keywords | Biochip Cyber-Physical System Error Detection and Recovery Microfluidics Sensor |
Issue Date | 2015 |
Citation | Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015, 2015, p. 224-227 How to Cite? |
Abstract | Microfluidic biochip technology integrates miniaturized components into a chip that can perform traditional biochemical laboratory procedures. Commercial impact is highlighted by the recent acquisition of Advanced Liquid Logic by Illumina Inc., a leader in DNA sequencing and biomolecular analysis. Due to the inherent variability involved in many biochemical processes, uncertainties manifest themselves in many ways in microluidics. Cyber-physical integration of on-chip sensors permits feedback-driven monitoring in-real time to detect and correct errors, along with other benefits such as adaptive control and dynamic re-synthesis. This paper overviews low-based and digital (droplet-based) microluidic biopchips, and discusses the state-of-The-Art in microluidic device fabrication, the interplay between sensor feedback and adaptive control software, and practical experiences relating to biochip cyber-physical integration. It demonstrates the connections between the many fundamental principles of chip design and engineering, and the needs of the biochip community. |
Persistent Identifier | http://hdl.handle.net/10722/336154 |
DC Field | Value | Language |
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dc.contributor.author | Ho, Tsung Yi | - |
dc.contributor.author | Grover, William | - |
dc.contributor.author | Hu, Shiyan | - |
dc.contributor.author | Chakrabarty, Krishnendu | - |
dc.date.accessioned | 2024-01-15T08:23:58Z | - |
dc.date.available | 2024-01-15T08:23:58Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015, 2015, p. 224-227 | - |
dc.identifier.uri | http://hdl.handle.net/10722/336154 | - |
dc.description.abstract | Microfluidic biochip technology integrates miniaturized components into a chip that can perform traditional biochemical laboratory procedures. Commercial impact is highlighted by the recent acquisition of Advanced Liquid Logic by Illumina Inc., a leader in DNA sequencing and biomolecular analysis. Due to the inherent variability involved in many biochemical processes, uncertainties manifest themselves in many ways in microluidics. Cyber-physical integration of on-chip sensors permits feedback-driven monitoring in-real time to detect and correct errors, along with other benefits such as adaptive control and dynamic re-synthesis. This paper overviews low-based and digital (droplet-based) microluidic biopchips, and discusses the state-of-The-Art in microluidic device fabrication, the interplay between sensor feedback and adaptive control software, and practical experiences relating to biochip cyber-physical integration. It demonstrates the connections between the many fundamental principles of chip design and engineering, and the needs of the biochip community. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the 33rd IEEE International Conference on Computer Design, ICCD 2015 | - |
dc.subject | Biochip | - |
dc.subject | Cyber-Physical System | - |
dc.subject | Error Detection and Recovery | - |
dc.subject | Microfluidics | - |
dc.subject | Sensor | - |
dc.title | Cyber-physical integration in programmable microfluidic biochips | - |
dc.type | Conference_Paper | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1109/ICCD.2015.7357107 | - |
dc.identifier.scopus | eid_2-s2.0-84962460161 | - |
dc.identifier.spage | 224 | - |
dc.identifier.epage | 227 | - |