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Article: Fusobacterium and Escherichia: Models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening

TitleFusobacterium and Escherichia: Models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening
Authors
Keywordsbiomarker
colorectal cancer
escherichia
fusobacterium
inflammation
Issue Date2015
Citation
Expert Review of Gastroenterology and Hepatology, 2015, v. 9, n. 5, p. 651-657 How to Cite?
AbstractIntestinal microbiota has emerging roles in the development of colorectal cancer (CRC). Intestinal dysbiosis, with altered levels of specific bacteria, is consistently seen in CRC. The heart of the debate lies in whether these bacteria are a cause or consequence of CRC. Two bacteria in particular, Fusobacterium nucleatum and Escherichia coli, have consistently been associated with CRC. This review will examine evidence supporting oncogenic roles of F. nucleatum and E. coli. The proposed mechanisms of tumor formation follow two models: bacterial induced chronic inflammation leads to cell proliferation and tumor formation and virulence factors directly induce tumor formation. This review will further examine the potential for microbiota as biomarkers in CRC, with a focus on F. nucleatum.
Persistent Identifierhttp://hdl.handle.net/10722/336136
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.090
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, Andrea-
dc.contributor.authorTsoi, Ho-
dc.contributor.authorYu, Jun-
dc.date.accessioned2024-01-15T08:23:48Z-
dc.date.available2024-01-15T08:23:48Z-
dc.date.issued2015-
dc.identifier.citationExpert Review of Gastroenterology and Hepatology, 2015, v. 9, n. 5, p. 651-657-
dc.identifier.issn1747-4124-
dc.identifier.urihttp://hdl.handle.net/10722/336136-
dc.description.abstractIntestinal microbiota has emerging roles in the development of colorectal cancer (CRC). Intestinal dysbiosis, with altered levels of specific bacteria, is consistently seen in CRC. The heart of the debate lies in whether these bacteria are a cause or consequence of CRC. Two bacteria in particular, Fusobacterium nucleatum and Escherichia coli, have consistently been associated with CRC. This review will examine evidence supporting oncogenic roles of F. nucleatum and E. coli. The proposed mechanisms of tumor formation follow two models: bacterial induced chronic inflammation leads to cell proliferation and tumor formation and virulence factors directly induce tumor formation. This review will further examine the potential for microbiota as biomarkers in CRC, with a focus on F. nucleatum.-
dc.languageeng-
dc.relation.ispartofExpert Review of Gastroenterology and Hepatology-
dc.subjectbiomarker-
dc.subjectcolorectal cancer-
dc.subjectescherichia-
dc.subjectfusobacterium-
dc.subjectinflammation-
dc.titleFusobacterium and Escherichia: Models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1586/17474124.2015.1001745-
dc.identifier.pmid25582922-
dc.identifier.scopuseid_2-s2.0-84928528828-
dc.identifier.volume9-
dc.identifier.issue5-
dc.identifier.spage651-
dc.identifier.epage657-
dc.identifier.eissn1747-4132-
dc.identifier.isiWOS:000353574200010-

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