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Article: Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants

TitleMonovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
Authors
Ong, Chon PhinTang, KaimingCheung, Pak Hin HinsonZhang, HongzhuoTang, Tze TungXue, YaqianWang, JunjueTo, Kelvin Kai WangYuan, ShuofengYe, Zi WeiJin, Dong Yan
Issue Date2023
Citation
npj Vaccines, 2023, v. 8, n. 1, article no. 177 How to Cite?
DOI: http://dx.doi.org/10.1038/s41541-023-00776-x
AbstractWe compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.
Persistent Identifierhttp://hdl.handle.net/10722/335908
ISI Accession Number ID
WOS:001105837300002

 

DC FieldValueLanguage
dc.contributor.authorOng, Chon Phin-
dc.contributor.authorTang, Kaiming-
dc.contributor.authorCheung, Pak Hin Hinson-
dc.contributor.authorZhang, Hongzhuo-
dc.contributor.authorTang, Tze Tung-
dc.contributor.authorXue, Yaqian-
dc.contributor.authorWang, Junjue-
dc.contributor.authorTo, Kelvin Kai Wang-
dc.contributor.authorYuan, Shuofeng-
dc.contributor.authorYe, Zi Wei-
dc.contributor.authorJin, Dong Yan-
dc.date.accessioned2023-12-28T08:49:39Z-
dc.date.available2023-12-28T08:49:39Z-
dc.date.issued2023-
dc.identifier.citationnpj Vaccines, 2023, v. 8, n. 1, article no. 177-
dc.identifier.urihttp://hdl.handle.net/10722/335908-
dc.description.abstractWe compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.-
dc.languageeng-
dc.relation.ispartofnpj Vaccines-
dc.titleMonovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41541-023-00776-x-
dc.identifier.scopuseid_2-s2.0-85177049833-
dc.identifier.volume8-
dc.identifier.issue1-
dc.identifier.spagearticle no. 177-
dc.identifier.epagearticle no. 177-
dc.identifier.eissn2059-0105-
dc.identifier.isiWOS:001105837300002-

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