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- Publisher Website: 10.1038/s41467-022-30474-6
- Scopus: eid_2-s2.0-85130317759
- PMID: 35589753
- WOS: WOS:000798347800019
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Article: A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway
Title | A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway |
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Authors | Parikh, Bhav HarshadLiu, ZengpingBlakeley, PaulLin, QianyuSingh, MalayOng, Jun YiHo, Kim HanLai, Joel WeijiaBogireddi, HanumakumarTran, Kim ChiLim, Jason Y.C.Xue, KunAl-Mubaarak, AbdurrahmaanYang, BinxiaSowmiya, R.Regha, KakkadWong, Daniel Soo LinTan, Queenie Shu WoonZhang, ZhongxingJeyasekharan, Anand D.Barathi, Veluchamy AmuthaYu, WeimiaoCheong, Kang HaoBlenkinsop, Timothy A.Hunziker, WalterLingam, GopalLoh, Xian JunSu, Xinyi |
Issue Date | 2022 |
Citation | Nature Communications, 2022, v. 13, n. 1, article no. 2796 How to Cite? |
Abstract | One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-proliferation of retinal pigment epithelial (RPE) cells. Current treatment relies primarily on surgical removal of these membranes. Here, we demonstrate that a bio-functional polymer by itself is able to prevent retinal scarring in an experimental rabbit model of proliferative vitreoretinopathy. This is mediated primarily via clathrin-dependent internalisation of polymeric micelles, downstream suppression of canonical EMT transcription factors, reduction of RPE cell hyper-proliferation and migration. Nuclear factor erythroid 2–related factor 2 signalling pathway was identified in a genome-wide transcriptomic profiling as a key sensor and effector. This study highlights the potential of using synthetic bio-functional polymer to modulate RPE cellular behaviour and offers a potential therapy for retinal scarring prevention. |
Persistent Identifier | http://hdl.handle.net/10722/335883 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Parikh, Bhav Harshad | - |
dc.contributor.author | Liu, Zengping | - |
dc.contributor.author | Blakeley, Paul | - |
dc.contributor.author | Lin, Qianyu | - |
dc.contributor.author | Singh, Malay | - |
dc.contributor.author | Ong, Jun Yi | - |
dc.contributor.author | Ho, Kim Han | - |
dc.contributor.author | Lai, Joel Weijia | - |
dc.contributor.author | Bogireddi, Hanumakumar | - |
dc.contributor.author | Tran, Kim Chi | - |
dc.contributor.author | Lim, Jason Y.C. | - |
dc.contributor.author | Xue, Kun | - |
dc.contributor.author | Al-Mubaarak, Abdurrahmaan | - |
dc.contributor.author | Yang, Binxia | - |
dc.contributor.author | Sowmiya, R. | - |
dc.contributor.author | Regha, Kakkad | - |
dc.contributor.author | Wong, Daniel Soo Lin | - |
dc.contributor.author | Tan, Queenie Shu Woon | - |
dc.contributor.author | Zhang, Zhongxing | - |
dc.contributor.author | Jeyasekharan, Anand D. | - |
dc.contributor.author | Barathi, Veluchamy Amutha | - |
dc.contributor.author | Yu, Weimiao | - |
dc.contributor.author | Cheong, Kang Hao | - |
dc.contributor.author | Blenkinsop, Timothy A. | - |
dc.contributor.author | Hunziker, Walter | - |
dc.contributor.author | Lingam, Gopal | - |
dc.contributor.author | Loh, Xian Jun | - |
dc.contributor.author | Su, Xinyi | - |
dc.date.accessioned | 2023-12-28T08:49:27Z | - |
dc.date.available | 2023-12-28T08:49:27Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Nature Communications, 2022, v. 13, n. 1, article no. 2796 | - |
dc.identifier.uri | http://hdl.handle.net/10722/335883 | - |
dc.description.abstract | One common cause of vision loss after retinal detachment surgery is the formation of proliferative and contractile fibrocellular membranes. This aberrant wound healing process is mediated by epithelial-mesenchymal transition (EMT) and hyper-proliferation of retinal pigment epithelial (RPE) cells. Current treatment relies primarily on surgical removal of these membranes. Here, we demonstrate that a bio-functional polymer by itself is able to prevent retinal scarring in an experimental rabbit model of proliferative vitreoretinopathy. This is mediated primarily via clathrin-dependent internalisation of polymeric micelles, downstream suppression of canonical EMT transcription factors, reduction of RPE cell hyper-proliferation and migration. Nuclear factor erythroid 2–related factor 2 signalling pathway was identified in a genome-wide transcriptomic profiling as a key sensor and effector. This study highlights the potential of using synthetic bio-functional polymer to modulate RPE cellular behaviour and offers a potential therapy for retinal scarring prevention. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Communications | - |
dc.title | A bio-functional polymer that prevents retinal scarring through modulation of NRF2 signalling pathway | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/s41467-022-30474-6 | - |
dc.identifier.pmid | 35589753 | - |
dc.identifier.scopus | eid_2-s2.0-85130317759 | - |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 2796 | - |
dc.identifier.epage | article no. 2796 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.isi | WOS:000798347800019 | - |