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Article: Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics

TitleSodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics
Authors
KeywordsApoptosis
Cardiovascular disease
Inflammation
Iron channel
Neoplasms
Oxidative stress
Sodium tanshinone IIA sulfonate
Traditional Chinese medicine
Transcription factor
Issue Date2019
Citation
Biomedicine and Pharmacotherapy, 2019, v. 118, article no. 109362 How to Cite?
AbstractSodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA) which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen). STS presents multiple pharmacological activities, including anti-oxidant, anti-inflammation and anti-apoptosis, and has been approved for treatment of cardiovascular diseases by China State Food and Drug Administration (CFDA). In this review, we comprehensively summarized the pharmacological activities and pharmacokinetics of STS, which could support the further application and development of STS. In the recent decades, numerous experimental and clinical studies have been conducted to investigate the potential treatment effects of STS in various diseases, such as heart diseases, brain diseases, pulmonary diseases, cancers, sepsis and so on. The underlying mechanisms were most related to anti-oxidative and anti-inflammatory effects of STS via regulating various transcription factors, such as NF-κB, Nrf2, Stat1/3, Smad2/3, Hif-1α and β-catenin. Iron channels, including Ca2+, K+ and Cl− channels, were also the important targets of STS. Additionally, we emphasized the differences between STS and Tan IIA despite the interchangeable use of Tan IIA and STS in many previous studies. It is promising to improve the efficacy and reduce side effects of chemotherapeutic drug by the combination use of STS in canner treatment. The application of STS in pregnancy needs to be seriously considered. Moreover, the drug-drug interactions between STS and other drugs needs to be further studied as well as the complications of STS.
Persistent Identifierhttp://hdl.handle.net/10722/335839
ISSN
2023 Impact Factor: 6.9
2023 SCImago Journal Rankings: 1.493
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhou, Zhong Yan-
dc.contributor.authorZhao, Wai Rong-
dc.contributor.authorZhang, Jing-
dc.contributor.authorChen, Xin Lin-
dc.contributor.authorTang, Jing Yi-
dc.date.accessioned2023-12-28T08:49:08Z-
dc.date.available2023-12-28T08:49:08Z-
dc.date.issued2019-
dc.identifier.citationBiomedicine and Pharmacotherapy, 2019, v. 118, article no. 109362-
dc.identifier.issn0753-3322-
dc.identifier.urihttp://hdl.handle.net/10722/335839-
dc.description.abstractSodium tanshinone IIA sulfonate (STS) is a water-soluble derivate of tanshinone IIA (Tan IIA) which is an active lipophilic constitute of Chinese Materia Medica Salvia miltiorrhiza Bge. (Danshen). STS presents multiple pharmacological activities, including anti-oxidant, anti-inflammation and anti-apoptosis, and has been approved for treatment of cardiovascular diseases by China State Food and Drug Administration (CFDA). In this review, we comprehensively summarized the pharmacological activities and pharmacokinetics of STS, which could support the further application and development of STS. In the recent decades, numerous experimental and clinical studies have been conducted to investigate the potential treatment effects of STS in various diseases, such as heart diseases, brain diseases, pulmonary diseases, cancers, sepsis and so on. The underlying mechanisms were most related to anti-oxidative and anti-inflammatory effects of STS via regulating various transcription factors, such as NF-κB, Nrf2, Stat1/3, Smad2/3, Hif-1α and β-catenin. Iron channels, including Ca2+, K+ and Cl− channels, were also the important targets of STS. Additionally, we emphasized the differences between STS and Tan IIA despite the interchangeable use of Tan IIA and STS in many previous studies. It is promising to improve the efficacy and reduce side effects of chemotherapeutic drug by the combination use of STS in canner treatment. The application of STS in pregnancy needs to be seriously considered. Moreover, the drug-drug interactions between STS and other drugs needs to be further studied as well as the complications of STS.-
dc.languageeng-
dc.relation.ispartofBiomedicine and Pharmacotherapy-
dc.subjectApoptosis-
dc.subjectCardiovascular disease-
dc.subjectInflammation-
dc.subjectIron channel-
dc.subjectNeoplasms-
dc.subjectOxidative stress-
dc.subjectSodium tanshinone IIA sulfonate-
dc.subjectTraditional Chinese medicine-
dc.subjectTranscription factor-
dc.titleSodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biopha.2019.109362-
dc.identifier.pmid31545252-
dc.identifier.scopuseid_2-s2.0-85071114881-
dc.identifier.volume118-
dc.identifier.spagearticle no. 109362-
dc.identifier.epagearticle no. 109362-
dc.identifier.eissn1950-6007-
dc.identifier.isiWOS:000486395000020-

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