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Article: Altered intrinsic connectivity distribution in internet gaming disorder and its associations with psychotherapy treatment outcomes

TitleAltered intrinsic connectivity distribution in internet gaming disorder and its associations with psychotherapy treatment outcomes
Authors
Keywordscraving behavioral intervention
internet gaming disorder
intrinsic connectivity distribution
resting-state fMRI
Issue Date2021
Citation
Addiction Biology, 2021, v. 26, n. 2, article no. e12917 How to Cite?
AbstractAlterations in brain connectivity have been implicated in internet gaming disorder (IGD). However, little is known about alterations in whole-brain connectivity and their associations with long-term treatment outcomes. Here, we used a relatively new analytic approach, intrinsic connectivity distribution (ICD) analysis, to examine brain connectivity in 74 IGD participants and 41 matched healthy controls (HCs) and conducted post hoc seed-based resting-state functional connectivity (rsFC) analyses based on the ICD findings. We also examined how these findings related to outcomes involving a craving behavioral intervention (CBI) for IGD. IGD participants showed less whole-brain connectivity in the left angular gyrus and ventromedial prefrontal cortex (vmPFC) compared with HC participants. Seed-based rsFC analyses revealed that the left angular gyrus in the IGD group showed less connectivity with areas involved in the default-mode network and greater connectivity with areas in the salience and executive control networks. CBI was associated with improved connectivity within regions in the default-mode network and regions across the default-mode and salience networks. ICD-identified connectivity differences in the left angular gyrus and vmPFC were related to changes in craving and severity of addiction 6 months after the intervention. The findings suggest that IGD is associated with alterations in brain connectivity that may be sensitive to interventions. Thus, the findings have implications for understanding mechanisms underlying CBI effects and for further treatment development.
Persistent Identifierhttp://hdl.handle.net/10722/335356
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 1.154
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Lu-
dc.contributor.authorPotenza, Marc N.-
dc.contributor.authorLacadie, Cheryl M.-
dc.contributor.authorZhang, Jin Tao-
dc.contributor.authorYip, Sarah W.-
dc.contributor.authorXia, Cui Cui-
dc.contributor.authorLan, Jing-
dc.contributor.authorYao, Yuan Wei-
dc.contributor.authorDeng, Lin Yuan-
dc.contributor.authorPark, Soyoung Q.-
dc.contributor.authorFang, Xiao Yi-
dc.date.accessioned2023-11-17T08:25:11Z-
dc.date.available2023-11-17T08:25:11Z-
dc.date.issued2021-
dc.identifier.citationAddiction Biology, 2021, v. 26, n. 2, article no. e12917-
dc.identifier.issn1355-6215-
dc.identifier.urihttp://hdl.handle.net/10722/335356-
dc.description.abstractAlterations in brain connectivity have been implicated in internet gaming disorder (IGD). However, little is known about alterations in whole-brain connectivity and their associations with long-term treatment outcomes. Here, we used a relatively new analytic approach, intrinsic connectivity distribution (ICD) analysis, to examine brain connectivity in 74 IGD participants and 41 matched healthy controls (HCs) and conducted post hoc seed-based resting-state functional connectivity (rsFC) analyses based on the ICD findings. We also examined how these findings related to outcomes involving a craving behavioral intervention (CBI) for IGD. IGD participants showed less whole-brain connectivity in the left angular gyrus and ventromedial prefrontal cortex (vmPFC) compared with HC participants. Seed-based rsFC analyses revealed that the left angular gyrus in the IGD group showed less connectivity with areas involved in the default-mode network and greater connectivity with areas in the salience and executive control networks. CBI was associated with improved connectivity within regions in the default-mode network and regions across the default-mode and salience networks. ICD-identified connectivity differences in the left angular gyrus and vmPFC were related to changes in craving and severity of addiction 6 months after the intervention. The findings suggest that IGD is associated with alterations in brain connectivity that may be sensitive to interventions. Thus, the findings have implications for understanding mechanisms underlying CBI effects and for further treatment development.-
dc.languageeng-
dc.relation.ispartofAddiction Biology-
dc.subjectcraving behavioral intervention-
dc.subjectinternet gaming disorder-
dc.subjectintrinsic connectivity distribution-
dc.subjectresting-state fMRI-
dc.titleAltered intrinsic connectivity distribution in internet gaming disorder and its associations with psychotherapy treatment outcomes-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/adb.12917-
dc.identifier.pmid32415913-
dc.identifier.scopuseid_2-s2.0-85084806796-
dc.identifier.volume26-
dc.identifier.issue2-
dc.identifier.spagearticle no. e12917-
dc.identifier.epagearticle no. e12917-
dc.identifier.eissn1369-1600-
dc.identifier.isiWOS:000532984300001-

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