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Article: Alterations in functional networks during cue-reactivity in Internet gaming disorder

TitleAlterations in functional networks during cue-reactivity in Internet gaming disorder
Authors
KeywordsBehavioral addiction
Cue-reactivity
Fmri
Functional brain networks
Ica
Internet gaming disorder
Issue Date2019
Citation
Journal of Behavioral Addictions, 2019, v. 8, n. 2, p. 277-287 How to Cite?
AbstractBackground: Cue-induced brain reactivity has been suggested to be a fundamental and important mechanism explaining the development, maintenance, and relapse of addiction, including Internet gaming disorder (IGD). Altered activity in addiction-related brain regions has been found during cue-reactivity in IGD using functional magnetic resonance imaging (fMRI), but less is known regarding the alterations of coordinated whole brain activity patterns in IGD. Methods: To investigate the activity of temporally coherent, large-scale functional brain networks (FNs) during cue-reactivity in IGD, independent component analysis was applied to fMRI data from 29 male subjects with IGD and 23 matched healthy controls (HC) performing a cue-reactivity task involving Internet gaming stimuli (i.e., game cues) and general Internet surfing-related stimuli (i.e., control cues). Results: Four FNs were identified that were related to the response to game cues relative to control cues and that showed altered engagement/disengagement in IGD compared with HC. These FNs included temporo-occipital and temporo-insula networks associated with sensory processing, a frontoparietal network involved in memory and executive functioning, and a dorsal-limbic network implicated in reward and motivation processing. Within IGD, game versus control engagement of the temporo-occipital and frontoparietal networks were positively correlated with IGD severity. Similarly, disengagement of temporo-insula network was negatively correlated with higher game-craving. Discussion: These findings are consistent with altered cue-reactivity brain regions reported in substance-related addictions, providing evidence that IGD may represent a type of addiction. The identification of the networks might shed light on the mechanisms of the cue-induced craving and addictive Internet gaming behaviors.
Persistent Identifierhttp://hdl.handle.net/10722/335336
ISSN
2023 Impact Factor: 6.6
2023 SCImago Journal Rankings: 2.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Shan Shan-
dc.contributor.authorWorhunsky, Patrick D.-
dc.contributor.authorXu, Jian Song-
dc.contributor.authorYip, Sarah W.-
dc.contributor.authorZhou, Nan-
dc.contributor.authorZhang, Jin Tao-
dc.contributor.authorLiu, Lu-
dc.contributor.authorWang, Ling Jiao-
dc.contributor.authorLiu, Ben-
dc.contributor.authorYao, Yuan Wei-
dc.contributor.authorZhang, Sheng-
dc.contributor.authorFang, Xiao Yi-
dc.date.accessioned2023-11-17T08:25:02Z-
dc.date.available2023-11-17T08:25:02Z-
dc.date.issued2019-
dc.identifier.citationJournal of Behavioral Addictions, 2019, v. 8, n. 2, p. 277-287-
dc.identifier.issn2062-5871-
dc.identifier.urihttp://hdl.handle.net/10722/335336-
dc.description.abstractBackground: Cue-induced brain reactivity has been suggested to be a fundamental and important mechanism explaining the development, maintenance, and relapse of addiction, including Internet gaming disorder (IGD). Altered activity in addiction-related brain regions has been found during cue-reactivity in IGD using functional magnetic resonance imaging (fMRI), but less is known regarding the alterations of coordinated whole brain activity patterns in IGD. Methods: To investigate the activity of temporally coherent, large-scale functional brain networks (FNs) during cue-reactivity in IGD, independent component analysis was applied to fMRI data from 29 male subjects with IGD and 23 matched healthy controls (HC) performing a cue-reactivity task involving Internet gaming stimuli (i.e., game cues) and general Internet surfing-related stimuli (i.e., control cues). Results: Four FNs were identified that were related to the response to game cues relative to control cues and that showed altered engagement/disengagement in IGD compared with HC. These FNs included temporo-occipital and temporo-insula networks associated with sensory processing, a frontoparietal network involved in memory and executive functioning, and a dorsal-limbic network implicated in reward and motivation processing. Within IGD, game versus control engagement of the temporo-occipital and frontoparietal networks were positively correlated with IGD severity. Similarly, disengagement of temporo-insula network was negatively correlated with higher game-craving. Discussion: These findings are consistent with altered cue-reactivity brain regions reported in substance-related addictions, providing evidence that IGD may represent a type of addiction. The identification of the networks might shed light on the mechanisms of the cue-induced craving and addictive Internet gaming behaviors.-
dc.languageeng-
dc.relation.ispartofJournal of Behavioral Addictions-
dc.subjectBehavioral addiction-
dc.subjectCue-reactivity-
dc.subjectFmri-
dc.subjectFunctional brain networks-
dc.subjectIca-
dc.subjectInternet gaming disorder-
dc.titleAlterations in functional networks during cue-reactivity in Internet gaming disorder-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1556/2006.8.2019.25-
dc.identifier.pmid31146550-
dc.identifier.scopuseid_2-s2.0-85068989003-
dc.identifier.volume8-
dc.identifier.issue2-
dc.identifier.spage277-
dc.identifier.epage287-
dc.identifier.eissn2063-5303-
dc.identifier.isiWOS:000488617600010-

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