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Article: Cohort profile: Zoe 2.0—a community-based genetic epidemiologic study of early childhood oral health

TitleCohort profile: Zoe 2.0—a community-based genetic epidemiologic study of early childhood oral health
Authors
KeywordsChildren
Community-based studies
Early childhood caries
Genomics
Oral health
Issue Date2020
Citation
International Journal of Environmental Research and Public Health, 2020, v. 17, n. 21, p. 1-16 How to Cite?
AbstractEarly childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals’ susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC (“ZOE 2.0”) is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study’s design, the cohort’s demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3–5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state’s 100 counties and racial/ethnic minorities predominated—for example, 48% (n = 3872) were African American, 22% white, and 20% (n = 1611) were Hispanic/Latino. Seventy-nine percent (n = 6404) of participants underwent clinical dental examinations yielding ECC outcome measures—ECC (defined at the established caries lesion threshold) prevalence was 54% and the mean number of decayed, missing, filled surfaces due to caries was eight. Nearly all (98%) examined children provided sufficient DNA from saliva for genotyping. The cohort’s community-based nature and rich data offer excellent opportunities for addressing important clinical, epidemiologic, and biological questions in early childhood.
Persistent Identifierhttp://hdl.handle.net/10722/334699
ISSN
2019 Impact Factor: 2.849
2023 SCImago Journal Rankings: 0.808
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDivaris, Kimon-
dc.contributor.authorSlade, Gary D.-
dc.contributor.authorFerreira Zandona, Andrea G.-
dc.contributor.authorPreisser, John S.-
dc.contributor.authorGinnis, Jeannie-
dc.contributor.authorSimancas-Pallares, Miguel A.-
dc.contributor.authorAgler, Cary S.-
dc.contributor.authorShrestha, Poojan-
dc.contributor.authorKarhade, Deepti S.-
dc.contributor.authorRibeiro, Apoena de Aguiar-
dc.contributor.authorCho, Hunyong-
dc.contributor.authorGu, Yu-
dc.contributor.authorMeyer, Beau D.-
dc.contributor.authorJoshi, Ashwini R.-
dc.contributor.authorAzcarate-Peril, M. Andrea-
dc.contributor.authorBasta, Patricia V.-
dc.contributor.authorWu, Di-
dc.contributor.authorNorth, Kari E.-
dc.date.accessioned2023-10-20T06:50:01Z-
dc.date.available2023-10-20T06:50:01Z-
dc.date.issued2020-
dc.identifier.citationInternational Journal of Environmental Research and Public Health, 2020, v. 17, n. 21, p. 1-16-
dc.identifier.issn1661-7827-
dc.identifier.urihttp://hdl.handle.net/10722/334699-
dc.description.abstractEarly childhood caries (ECC) is an aggressive form of dental caries occurring in the first five years of life. Despite its prevalence and consequences, little progress has been made in its prevention and even less is known about individuals’ susceptibility or genomic risk factors. The genome-wide association study (GWAS) of ECC (“ZOE 2.0”) is a community-based, multi-ethnic, cross-sectional, genetic epidemiologic study seeking to address this knowledge gap. This paper describes the study’s design, the cohort’s demographic profile, data domains, and key oral health outcomes. Between 2016 and 2019, the study enrolled 8059 3–5-year-old children attending public preschools in North Carolina, United States. Participants resided in 86 of the state’s 100 counties and racial/ethnic minorities predominated—for example, 48% (n = 3872) were African American, 22% white, and 20% (n = 1611) were Hispanic/Latino. Seventy-nine percent (n = 6404) of participants underwent clinical dental examinations yielding ECC outcome measures—ECC (defined at the established caries lesion threshold) prevalence was 54% and the mean number of decayed, missing, filled surfaces due to caries was eight. Nearly all (98%) examined children provided sufficient DNA from saliva for genotyping. The cohort’s community-based nature and rich data offer excellent opportunities for addressing important clinical, epidemiologic, and biological questions in early childhood.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Environmental Research and Public Health-
dc.subjectChildren-
dc.subjectCommunity-based studies-
dc.subjectEarly childhood caries-
dc.subjectGenomics-
dc.subjectOral health-
dc.titleCohort profile: Zoe 2.0—a community-based genetic epidemiologic study of early childhood oral health-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3390/ijerph17218056-
dc.identifier.pmid33139633-
dc.identifier.scopuseid_2-s2.0-85094868859-
dc.identifier.volume17-
dc.identifier.issue21-
dc.identifier.spage1-
dc.identifier.epage16-
dc.identifier.eissn1660-4601-
dc.identifier.isiWOS:000588902700001-

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