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Article: Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties

TitleCarbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties
Authors
Issue Date2020
Citation
Nature Biomedical Engineering, 2020, v. 4, n. 3, p. 325-334 How to Cite?
AbstractThe low magnetic saturation of iron oxide nanoparticles, which are developed primarily as contrast agents for magnetic resonance imaging, limits the sensitivity of their detection using magnetic particle imaging (MPI). Here, we show that FeCo nanoparticles that have a core diameter of 10 nm and bear a graphitic carbon shell decorated with poly(ethylene glycol) provide an MPI signal intensity that is sixfold and fifteenfold higher than the signals from the superparamagnetic iron oxide tracers VivoTrax and Feraheme, respectively, at the same molar concentration of iron. We also show that the nanoparticles have photothermal and magnetothermal properties and can therefore be used for tumour ablation in mice, and that they have high optical absorbance in a broad near-infrared region spectral range (wavelength, 700–1,200 nm), making them suitable as tracers for photoacoustic imaging. As sensitive multifunctional and multimodal imaging tracers, carbon-coated FeCo nanoparticles may confer advantages in cancer imaging and hyperthermia therapy.
Persistent Identifierhttp://hdl.handle.net/10722/334641
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSong, Guosheng-
dc.contributor.authorKenney, Michael-
dc.contributor.authorChen, Yun Sheng-
dc.contributor.authorZheng, Xianchuang-
dc.contributor.authorDeng, Yong-
dc.contributor.authorChen, Zhuo-
dc.contributor.authorWang, Shan X.-
dc.contributor.authorGambhir, Sanjiv Sam-
dc.contributor.authorDai, Hongjie-
dc.contributor.authorRao, Jianghong-
dc.date.accessioned2023-10-20T06:49:36Z-
dc.date.available2023-10-20T06:49:36Z-
dc.date.issued2020-
dc.identifier.citationNature Biomedical Engineering, 2020, v. 4, n. 3, p. 325-334-
dc.identifier.urihttp://hdl.handle.net/10722/334641-
dc.description.abstractThe low magnetic saturation of iron oxide nanoparticles, which are developed primarily as contrast agents for magnetic resonance imaging, limits the sensitivity of their detection using magnetic particle imaging (MPI). Here, we show that FeCo nanoparticles that have a core diameter of 10 nm and bear a graphitic carbon shell decorated with poly(ethylene glycol) provide an MPI signal intensity that is sixfold and fifteenfold higher than the signals from the superparamagnetic iron oxide tracers VivoTrax and Feraheme, respectively, at the same molar concentration of iron. We also show that the nanoparticles have photothermal and magnetothermal properties and can therefore be used for tumour ablation in mice, and that they have high optical absorbance in a broad near-infrared region spectral range (wavelength, 700–1,200 nm), making them suitable as tracers for photoacoustic imaging. As sensitive multifunctional and multimodal imaging tracers, carbon-coated FeCo nanoparticles may confer advantages in cancer imaging and hyperthermia therapy.-
dc.languageeng-
dc.relation.ispartofNature Biomedical Engineering-
dc.titleCarbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41551-019-0506-0-
dc.identifier.pmid32015409-
dc.identifier.scopuseid_2-s2.0-85078888844-
dc.identifier.volume4-
dc.identifier.issue3-
dc.identifier.spage325-
dc.identifier.epage334-
dc.identifier.eissn2157-846X-
dc.identifier.isiWOS:000510821600002-

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