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- Publisher Website: 10.1002/adma.201900321
- Scopus: eid_2-s2.0-85065045437
- PMID: 31025403
- WOS: WOS:000485478200011
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Article: Near-Infrared-II Molecular Dyes for Cancer Imaging and Surgery
Title | Near-Infrared-II Molecular Dyes for Cancer Imaging and Surgery |
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Authors | |
Keywords | cyanine dyes donor–acceptor–donor dyes near-infrared (NIR)-II fluorophores near-infrared (NIR)-II imaging tumor imaging |
Issue Date | 2019 |
Citation | Advanced Materials, 2019, v. 31, n. 24, article no. 1900321 How to Cite? |
Abstract | Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target a variety of biological tissues and processes. This review focuses on summarizing organic dyes emitting at a biological transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with the surrounding tissues allows photons to travel nearly unperturbed throughout the body. NIR-II fluorescence imaging overcomes the penetration/contrast bottleneck of imaging in the visible region, making it a remarkable modality for early diagnosis of cancer and highly sensitive tumor surgery. Due to their convenient bioconjugation with peptides/antibodies, NIR-II molecular dyes are desirable candidates for targeted cancer imaging, significantly overcoming the autofluorescence/scattering issues for deep tissue molecular imaging. To promote the clinical translation of NIR-II bioimaging, advancements in the high-performance small molecule–derived probes are critically important. Here, molecules with clinical potential for NIR-II imaging are discussed, summarizing the synthesis and chemical structures of NIR-II dyes, chemical and optical properties of NIR-II dyes, bioconjugation and biological behavior of NIR-II dyes, whole body imaging with NIR-II dyes for cancer detection and surgery, as well as NIR-II fluorescence microscopy imaging. A key perspective on the direction of NIR-II molecular dyes for cancer imaging and surgery is also discussed. |
Persistent Identifier | http://hdl.handle.net/10722/334590 |
ISSN | 2023 Impact Factor: 27.4 2023 SCImago Journal Rankings: 9.191 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhu, Shoujun | - |
dc.contributor.author | Tian, Rui | - |
dc.contributor.author | Antaris, Alexander L. | - |
dc.contributor.author | Chen, Xiaoyuan | - |
dc.contributor.author | Dai, Hongjie | - |
dc.date.accessioned | 2023-10-20T06:49:13Z | - |
dc.date.available | 2023-10-20T06:49:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Advanced Materials, 2019, v. 31, n. 24, article no. 1900321 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | http://hdl.handle.net/10722/334590 | - |
dc.description.abstract | Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target a variety of biological tissues and processes. This review focuses on summarizing organic dyes emitting at a biological transparency window termed the near-infrared-II (NIR-II) window, where minimal light interaction with the surrounding tissues allows photons to travel nearly unperturbed throughout the body. NIR-II fluorescence imaging overcomes the penetration/contrast bottleneck of imaging in the visible region, making it a remarkable modality for early diagnosis of cancer and highly sensitive tumor surgery. Due to their convenient bioconjugation with peptides/antibodies, NIR-II molecular dyes are desirable candidates for targeted cancer imaging, significantly overcoming the autofluorescence/scattering issues for deep tissue molecular imaging. To promote the clinical translation of NIR-II bioimaging, advancements in the high-performance small molecule–derived probes are critically important. Here, molecules with clinical potential for NIR-II imaging are discussed, summarizing the synthesis and chemical structures of NIR-II dyes, chemical and optical properties of NIR-II dyes, bioconjugation and biological behavior of NIR-II dyes, whole body imaging with NIR-II dyes for cancer detection and surgery, as well as NIR-II fluorescence microscopy imaging. A key perspective on the direction of NIR-II molecular dyes for cancer imaging and surgery is also discussed. | - |
dc.language | eng | - |
dc.relation.ispartof | Advanced Materials | - |
dc.subject | cyanine dyes | - |
dc.subject | donor–acceptor–donor dyes | - |
dc.subject | near-infrared (NIR)-II fluorophores | - |
dc.subject | near-infrared (NIR)-II imaging | - |
dc.subject | tumor imaging | - |
dc.title | Near-Infrared-II Molecular Dyes for Cancer Imaging and Surgery | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/adma.201900321 | - |
dc.identifier.pmid | 31025403 | - |
dc.identifier.scopus | eid_2-s2.0-85065045437 | - |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 24 | - |
dc.identifier.spage | article no. 1900321 | - |
dc.identifier.epage | article no. 1900321 | - |
dc.identifier.eissn | 1521-4095 | - |
dc.identifier.isi | WOS:000485478200011 | - |