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Article: Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe

TitleMolecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe
Authors
Keywordsmolecular imaging
peptide probe
renal-excretion
second near-infrared window
tumor targeting
Issue Date2018
Citation
Advanced Materials, 2018, v. 30, n. 22, article no. 1800106 How to Cite?
AbstractIn vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. While targeted imaging often relies on antibody-modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) shows promise in reaching sub-centimeter depth with microscale resolution. Here, a novel peptide (named CP) conjugated NIR-II fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker CD133. The click chemistry derived peptide-dye (CP-IRT dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor-to-normal tissue signal ratio (T/NT > 8). Importantly, the CP-IRT probes are rapidly renal excreted (≈87% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody-dye probes. Further, with NIR-II emitting CP-IRT probes, urethra of mice can be imaged fluorescently for the first time noninvasively through intact tissue. The NIR-II fluorescent, CD133 targeting imaging probes are potentially useful for human use in the clinic for cancer diagnosis and therapy.
Persistent Identifierhttp://hdl.handle.net/10722/334543
ISSN
2023 Impact Factor: 27.4
2023 SCImago Journal Rankings: 9.191
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Weizhi-
dc.contributor.authorMa, Zhuoran-
dc.contributor.authorZhu, Shoujun-
dc.contributor.authorWan, Hao-
dc.contributor.authorYue, Jingying-
dc.contributor.authorMa, Huilong-
dc.contributor.authorMa, Rui-
dc.contributor.authorYang, Qinglai-
dc.contributor.authorWang, Zihua-
dc.contributor.authorLi, Qian-
dc.contributor.authorQian, Yixia-
dc.contributor.authorYue, Chunyan-
dc.contributor.authorWang, Yuehua-
dc.contributor.authorFan, Linyang-
dc.contributor.authorZhong, Yeteng-
dc.contributor.authorZhou, Ying-
dc.contributor.authorGao, Hongpeng-
dc.contributor.authorRuan, Junshan-
dc.contributor.authorHu, Zhiyuan-
dc.contributor.authorLiang, Yongye-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:48:53Z-
dc.date.available2023-10-20T06:48:53Z-
dc.date.issued2018-
dc.identifier.citationAdvanced Materials, 2018, v. 30, n. 22, article no. 1800106-
dc.identifier.issn0935-9648-
dc.identifier.urihttp://hdl.handle.net/10722/334543-
dc.description.abstractIn vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. While targeted imaging often relies on antibody-modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1000–1700 nm) shows promise in reaching sub-centimeter depth with microscale resolution. Here, a novel peptide (named CP) conjugated NIR-II fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker CD133. The click chemistry derived peptide-dye (CP-IRT dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor-to-normal tissue signal ratio (T/NT > 8). Importantly, the CP-IRT probes are rapidly renal excreted (≈87% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody-dye probes. Further, with NIR-II emitting CP-IRT probes, urethra of mice can be imaged fluorescently for the first time noninvasively through intact tissue. The NIR-II fluorescent, CD133 targeting imaging probes are potentially useful for human use in the clinic for cancer diagnosis and therapy.-
dc.languageeng-
dc.relation.ispartofAdvanced Materials-
dc.subjectmolecular imaging-
dc.subjectpeptide probe-
dc.subjectrenal-excretion-
dc.subjectsecond near-infrared window-
dc.subjecttumor targeting-
dc.titleMolecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adma.201800106-
dc.identifier.pmid29682821-
dc.identifier.scopuseid_2-s2.0-85047800333-
dc.identifier.volume30-
dc.identifier.issue22-
dc.identifier.spagearticle no. 1800106-
dc.identifier.epagearticle no. 1800106-
dc.identifier.eissn1521-4095-
dc.identifier.isiWOS:000434034100025-

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