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Article: A bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues

TitleA bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues
Authors
Issue Date2018
Citation
Nature Communications, 2018, v. 9, n. 1, article no. 1171 How to Cite?
AbstractFluorescence imaging of biological systems in the second near-infrared (NIR-II, 1000-1700 nm) window has shown promise of high spatial resolution, low background, and deep tissue penetration owing to low autofluorescence and suppressed scattering of long wavelength photons. Here we develop a bright organic nanofluorophore (named p-FE) for high-performance biological imaging in the NIR-II window. The bright NIR-II >1100 nm fluorescence emission from p-FE affords non-invasive in vivo tracking of blood flow in mouse brain vessels. Excitingly, p-FE enables one-photon based, three-dimensional (3D) confocal imaging of vasculatures in fixed mouse brain tissue with a layer-by-layer imaging depth up to ∼1.3 mm and sub-10 μm high spatial resolution. We also perform in vivo two-color fluorescence imaging in the NIR-II window by utilizing p-FE as a vasculature imaging agent emitting between 1100 and 1300 nm and single-walled carbon nanotubes (CNTs) emitting above 1500 nm to highlight tumors in mice.
Persistent Identifierhttp://hdl.handle.net/10722/334533
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWan, Hao-
dc.contributor.authorYue, Jingying-
dc.contributor.authorZhu, Shoujun-
dc.contributor.authorUno, Takaaki-
dc.contributor.authorZhang, Xiaodong-
dc.contributor.authorYang, Qinglai-
dc.contributor.authorYu, Kuai-
dc.contributor.authorHong, Guosong-
dc.contributor.authorWang, Junying-
dc.contributor.authorLi, Lulin-
dc.contributor.authorMa, Zhuoran-
dc.contributor.authorGao, Hongpeng-
dc.contributor.authorZhong, Yeteng-
dc.contributor.authorSu, Jessica-
dc.contributor.authorAntaris, Alexander L.-
dc.contributor.authorXia, Yan-
dc.contributor.authorLuo, Jian-
dc.contributor.authorLiang, Yongye-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:48:49Z-
dc.date.available2023-10-20T06:48:49Z-
dc.date.issued2018-
dc.identifier.citationNature Communications, 2018, v. 9, n. 1, article no. 1171-
dc.identifier.urihttp://hdl.handle.net/10722/334533-
dc.description.abstractFluorescence imaging of biological systems in the second near-infrared (NIR-II, 1000-1700 nm) window has shown promise of high spatial resolution, low background, and deep tissue penetration owing to low autofluorescence and suppressed scattering of long wavelength photons. Here we develop a bright organic nanofluorophore (named p-FE) for high-performance biological imaging in the NIR-II window. The bright NIR-II >1100 nm fluorescence emission from p-FE affords non-invasive in vivo tracking of blood flow in mouse brain vessels. Excitingly, p-FE enables one-photon based, three-dimensional (3D) confocal imaging of vasculatures in fixed mouse brain tissue with a layer-by-layer imaging depth up to ∼1.3 mm and sub-10 μm high spatial resolution. We also perform in vivo two-color fluorescence imaging in the NIR-II window by utilizing p-FE as a vasculature imaging agent emitting between 1100 and 1300 nm and single-walled carbon nanotubes (CNTs) emitting above 1500 nm to highlight tumors in mice.-
dc.languageeng-
dc.relation.ispartofNature Communications-
dc.titleA bright organic NIR-II nanofluorophore for three-dimensional imaging into biological tissues-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41467-018-03505-4-
dc.identifier.pmid29563581-
dc.identifier.scopuseid_2-s2.0-85044459609-
dc.identifier.volume9-
dc.identifier.issue1-
dc.identifier.spagearticle no. 1171-
dc.identifier.epagearticle no. 1171-
dc.identifier.eissn2041-1723-
dc.identifier.isiWOS:000427929200002-

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