File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window

TitleUltrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window
Authors
Issue Date2014
Citation
Nature Communications, 2014, v. 5, article no. 4206 How to Cite?
AbstractIn vivo fluorescence imaging in the second near-infrared window (1.0-1.7 μm) can afford deep tissue penetration and high spatial resolution, owing to the reduced scattering of long-wavelength photons. Here we synthesize a series of low-bandgap donor/acceptor copolymers with tunable emission wavelengths of 1,050-1,350 nm in this window. Non-covalent functionalization with phospholipid-polyethylene glycol results in water-soluble and biocompatible polymeric nanoparticles, allowing for live cell molecular imaging at >1,000 nm with polymer fluorophores for the first time. Importantly, the high quantum yield of the polymer allows for in vivo, deep-tissue and ultrafast imaging of mouse arterial blood flow with an unprecedented frame rate of >25 frames per second. The high time-resolution results in spatially and time resolved imaging of the blood flow pattern in cardiogram waveform over a single cardiac cycle (∼200 ms) of a mouse, which has not been observed with fluorescence imaging in this window before. © 2014 Macmillan Publishers Limited.
Persistent Identifierhttp://hdl.handle.net/10722/334359
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHong, Guosong-
dc.contributor.authorZou, Yingping-
dc.contributor.authorAntaris, Alexander L.-
dc.contributor.authorDiao, Shuo-
dc.contributor.authorWu, Di-
dc.contributor.authorCheng, Kai-
dc.contributor.authorZhang, Xiaodong-
dc.contributor.authorChen, Changxin-
dc.contributor.authorLiu, Bo-
dc.contributor.authorHe, Yuehui-
dc.contributor.authorWu, Justin Z.-
dc.contributor.authorYuan, Jun-
dc.contributor.authorZhang, Bo-
dc.contributor.authorTao, Zhimin-
dc.contributor.authorFukunaga, Chihiro-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:47:35Z-
dc.date.available2023-10-20T06:47:35Z-
dc.date.issued2014-
dc.identifier.citationNature Communications, 2014, v. 5, article no. 4206-
dc.identifier.urihttp://hdl.handle.net/10722/334359-
dc.description.abstractIn vivo fluorescence imaging in the second near-infrared window (1.0-1.7 μm) can afford deep tissue penetration and high spatial resolution, owing to the reduced scattering of long-wavelength photons. Here we synthesize a series of low-bandgap donor/acceptor copolymers with tunable emission wavelengths of 1,050-1,350 nm in this window. Non-covalent functionalization with phospholipid-polyethylene glycol results in water-soluble and biocompatible polymeric nanoparticles, allowing for live cell molecular imaging at >1,000 nm with polymer fluorophores for the first time. Importantly, the high quantum yield of the polymer allows for in vivo, deep-tissue and ultrafast imaging of mouse arterial blood flow with an unprecedented frame rate of >25 frames per second. The high time-resolution results in spatially and time resolved imaging of the blood flow pattern in cardiogram waveform over a single cardiac cycle (∼200 ms) of a mouse, which has not been observed with fluorescence imaging in this window before. © 2014 Macmillan Publishers Limited.-
dc.languageeng-
dc.relation.ispartofNature Communications-
dc.titleUltrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ncomms5206-
dc.identifier.pmid24947309-
dc.identifier.scopuseid_2-s2.0-84903155801-
dc.identifier.volume5-
dc.identifier.spagearticle no. 4206-
dc.identifier.epagearticle no. 4206-
dc.identifier.eissn2041-1723-
dc.identifier.isiWOS:000338839100002-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats