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Article: Expression and regulation of Runx3 in mouse uterus during the peri-implantation period.

TitleExpression and regulation of Runx3 in mouse uterus during the peri-implantation period.
Authors
Issue Date2013
Citation
Journal of molecular histology, 2013, v. 44, n. 5, p. 519-526 How to Cite?
AbstractThe aim of this study was to investigate the differential expression and regulation of Runt-related transcription factor 3 (Runx3) in mouse uterus during early pregnancy and its regulation by steroid hormones using in situ hybridization. There was a low level of the Runx3 mRNA expression in the mouse uterus on days 1-4 of pregnancy. On day 5 when embryo implanted, Runx3 mRNA signal was obviously observed in the stromal cells surrounding the implanting blastocyst. From day 6 to 8 of pregnancy, Runx3 mRNA was highly expressed in the decidual cells and mesometrial decidual beds. Similarly, Runx3 mRNA was strongly expressed in decidualized cells under artificial decidualization. Compared with the delayed uterus, a high level of Runx3 mRNA signal was detected in the uterus with activated implantation. In the ovariectomized mouse uterus, estrogen could induce the expression of Runx3, while progesterone had no effects. These results suggest that Runx3 may play an important role during mouse implantation and decidualization. Estrogen can induce the expression of Runx3 in the ovariectomized mouse uterus.
Persistent Identifierhttp://hdl.handle.net/10722/334356
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBai, Zhi Kun-
dc.contributor.authorGuo, Bin-
dc.contributor.authorTian, Xue Chao-
dc.contributor.authorLi, Dang Dang-
dc.contributor.authorWang, Shou Tang-
dc.contributor.authorCao, Hang-
dc.contributor.authorWang, Qu Yuan-
dc.contributor.authorYue, Zhan Peng-
dc.date.accessioned2023-10-20T06:47:34Z-
dc.date.available2023-10-20T06:47:34Z-
dc.date.issued2013-
dc.identifier.citationJournal of molecular histology, 2013, v. 44, n. 5, p. 519-526-
dc.identifier.urihttp://hdl.handle.net/10722/334356-
dc.description.abstractThe aim of this study was to investigate the differential expression and regulation of Runt-related transcription factor 3 (Runx3) in mouse uterus during early pregnancy and its regulation by steroid hormones using in situ hybridization. There was a low level of the Runx3 mRNA expression in the mouse uterus on days 1-4 of pregnancy. On day 5 when embryo implanted, Runx3 mRNA signal was obviously observed in the stromal cells surrounding the implanting blastocyst. From day 6 to 8 of pregnancy, Runx3 mRNA was highly expressed in the decidual cells and mesometrial decidual beds. Similarly, Runx3 mRNA was strongly expressed in decidualized cells under artificial decidualization. Compared with the delayed uterus, a high level of Runx3 mRNA signal was detected in the uterus with activated implantation. In the ovariectomized mouse uterus, estrogen could induce the expression of Runx3, while progesterone had no effects. These results suggest that Runx3 may play an important role during mouse implantation and decidualization. Estrogen can induce the expression of Runx3 in the ovariectomized mouse uterus.-
dc.languageeng-
dc.relation.ispartofJournal of molecular histology-
dc.titleExpression and regulation of Runx3 in mouse uterus during the peri-implantation period.-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10735-013-9501-z-
dc.identifier.pmid23572423-
dc.identifier.scopuseid_2-s2.0-84899035663-
dc.identifier.volume44-
dc.identifier.issue5-
dc.identifier.spage519-
dc.identifier.epage526-
dc.identifier.eissn1567-2387-
dc.identifier.isiWOS:000325160700003-

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