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Article: Graphite-coated magnetic nanoparticle microarray for few-cells enrichment and detection

TitleGraphite-coated magnetic nanoparticle microarray for few-cells enrichment and detection
Authors
Keywordscells detection
graphite
magnetic nanoparticle
microarray
polymer modification
Issue Date2012
Citation
ACS Nano, 2012, v. 6, n. 2, p. 1094-1101 How to Cite?
AbstractGraphite-coated, highly magnetic FeCo core-shell nanoparticles were synthesized by a chemical vapor deposition method and solubilized in aqueous solution through a unique polymer mixture modification, which significantly improved the biocompatibility and stability of the magnetic nanoparticles (MNPs). Such functionalized MNPs were proven to be very stable in different conditions which would be significant for biological applications. Cell staining, manipulation, enrichment, and detection were developed with these MNPs. Under external magnetic manipulation, the MNP-stained cells exhibited directed motions. Moreover, MNPs were printed on substrates to modulate the magnetic field distribution on the surface. Capture and detection of sparse populations of cancer cells spiked into whole blood has been explored in a microarray fashion. Cancer cells from hundreds down to only two were able to be simply and efficiently detected from 1 mL of whole blood on the MNP microarray chips. Interestingly, the cells captured through the MNP microarray still showed viability and adhered to the MNP spots after incubation, which could be utilized for cancer cell detection, localized growth, and proliferation. © 2012 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/334268
ISSN
2023 Impact Factor: 15.8
2023 SCImago Journal Rankings: 4.593
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Zhuo-
dc.contributor.authorHong, Guosong-
dc.contributor.authorWang, Hailiang-
dc.contributor.authorWelsher, Kevin-
dc.contributor.authorTabakman, Scott M.-
dc.contributor.authorSherlock, Sarah P.-
dc.contributor.authorRobinson, Joshua T.-
dc.contributor.authorLiang, Yongye-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:46:55Z-
dc.date.available2023-10-20T06:46:55Z-
dc.date.issued2012-
dc.identifier.citationACS Nano, 2012, v. 6, n. 2, p. 1094-1101-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/334268-
dc.description.abstractGraphite-coated, highly magnetic FeCo core-shell nanoparticles were synthesized by a chemical vapor deposition method and solubilized in aqueous solution through a unique polymer mixture modification, which significantly improved the biocompatibility and stability of the magnetic nanoparticles (MNPs). Such functionalized MNPs were proven to be very stable in different conditions which would be significant for biological applications. Cell staining, manipulation, enrichment, and detection were developed with these MNPs. Under external magnetic manipulation, the MNP-stained cells exhibited directed motions. Moreover, MNPs were printed on substrates to modulate the magnetic field distribution on the surface. Capture and detection of sparse populations of cancer cells spiked into whole blood has been explored in a microarray fashion. Cancer cells from hundreds down to only two were able to be simply and efficiently detected from 1 mL of whole blood on the MNP microarray chips. Interestingly, the cells captured through the MNP microarray still showed viability and adhered to the MNP spots after incubation, which could be utilized for cancer cell detection, localized growth, and proliferation. © 2012 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofACS Nano-
dc.subjectcells detection-
dc.subjectgraphite-
dc.subjectmagnetic nanoparticle-
dc.subjectmicroarray-
dc.subjectpolymer modification-
dc.titleGraphite-coated magnetic nanoparticle microarray for few-cells enrichment and detection-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/nn2034692-
dc.identifier.pmid22229344-
dc.identifier.scopuseid_2-s2.0-84857722588-
dc.identifier.volume6-
dc.identifier.issue2-
dc.identifier.spage1094-
dc.identifier.epage1101-
dc.identifier.eissn1936-086X-
dc.identifier.isiWOS:000300757900013-

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