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- Publisher Website: 10.1002/smll.201001836
- Scopus: eid_2-s2.0-79952286065
- PMID: 21360809
- WOS: WOS:000288080400011
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Article: A new approach to solution-phase gold seeding for SERS substrates
Title | A new approach to solution-phase gold seeding for SERS substrates |
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Authors | |
Keywords | bioassay gold nanoparticles nanotechnology plasmonics surface-enhanced Raman scattering |
Issue Date | 2011 |
Citation | Small, 2011, v. 7, n. 4, p. 499-505 How to Cite? |
Abstract | Surface-enhanced Raman scattering (SERS) vastly improves signal-to-noise ratios as compared to traditional Raman scattering, making sensitive assays based upon Raman scattering a reality. However, preparation of highly stable SERS-active gold substrates requires complicated and expensive methodologies and instrumentation. Here, a general and completely solution-phase, seed-based approach is introduced, which is capable of producing gold films for SERS applications on a variety of substrates, not requiring surface modification or functionalization. SERS enhancement factors of ≈107 were observed. Moreover, solution-phase gold film deposition on highly complex surfaces, such as protein-coated bioassays, is demonstrated for the first time. Protein bioassays coated with such SERS-active gold films are combined with bioconjugated single-walled carbon nanotube Raman labels, affording highly sensitive detection of the cancer biomarker, carcinoembryonic antigen in serum, with a limit of detection of ≈5 fM (1 pg mL-1). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Persistent Identifier | http://hdl.handle.net/10722/334233 |
ISSN | 2023 Impact Factor: 13.0 2023 SCImago Journal Rankings: 3.348 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tabakman, Scott M. | - |
dc.contributor.author | Chen, Zhuo | - |
dc.contributor.author | Casalongue, Hernan Sanchez | - |
dc.contributor.author | Wang, Hailiang | - |
dc.contributor.author | Dai, Hongjie | - |
dc.date.accessioned | 2023-10-20T06:46:40Z | - |
dc.date.available | 2023-10-20T06:46:40Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Small, 2011, v. 7, n. 4, p. 499-505 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | http://hdl.handle.net/10722/334233 | - |
dc.description.abstract | Surface-enhanced Raman scattering (SERS) vastly improves signal-to-noise ratios as compared to traditional Raman scattering, making sensitive assays based upon Raman scattering a reality. However, preparation of highly stable SERS-active gold substrates requires complicated and expensive methodologies and instrumentation. Here, a general and completely solution-phase, seed-based approach is introduced, which is capable of producing gold films for SERS applications on a variety of substrates, not requiring surface modification or functionalization. SERS enhancement factors of ≈107 were observed. Moreover, solution-phase gold film deposition on highly complex surfaces, such as protein-coated bioassays, is demonstrated for the first time. Protein bioassays coated with such SERS-active gold films are combined with bioconjugated single-walled carbon nanotube Raman labels, affording highly sensitive detection of the cancer biomarker, carcinoembryonic antigen in serum, with a limit of detection of ≈5 fM (1 pg mL-1). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | - |
dc.language | eng | - |
dc.relation.ispartof | Small | - |
dc.subject | bioassay | - |
dc.subject | gold nanoparticles | - |
dc.subject | nanotechnology | - |
dc.subject | plasmonics | - |
dc.subject | surface-enhanced Raman scattering | - |
dc.title | A new approach to solution-phase gold seeding for SERS substrates | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/smll.201001836 | - |
dc.identifier.pmid | 21360809 | - |
dc.identifier.scopus | eid_2-s2.0-79952286065 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 499 | - |
dc.identifier.epage | 505 | - |
dc.identifier.eissn | 1613-6829 | - |
dc.identifier.isi | WOS:000288080400011 | - |