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- Publisher Website: 10.1021/ja109042w
- Scopus: eid_2-s2.0-78650128025
- PMID: 21090719
- WOS: WOS:000285328800024
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Article: A dual platform for selective analyte enrichment and ionization in mass spectrometry using aptamer-conjugated graphene oxide
Title | A dual platform for selective analyte enrichment and ionization in mass spectrometry using aptamer-conjugated graphene oxide |
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Authors | |
Issue Date | 2010 |
Citation | Journal of the American Chemical Society, 2010, v. 132, n. 49, p. 17408-17410 How to Cite? |
Abstract | This study demonstrates the use of aptamer-conjugated graphene oxide as an affinity extraction and detection platform for analytes from complex biological media. We have shown that cocaine and adenosine can be selectively enriched from plasma samples and that direct mass spectrometric readouts can be obtained without a matrix and with greatly improved signal-to-noise ratios. Aptamer-conjugated graphene oxide has clear advantages in target enrichment and in generating highly efficient ionization of target molecules for mass spectrometry. These results demonstrate the utility of the approach for analysis of small molecules in real biological samples. © 2010 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/334226 |
ISSN | 2023 Impact Factor: 14.4 2023 SCImago Journal Rankings: 5.489 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Gulbakan, Basri | - |
dc.contributor.author | Yasun, Emir | - |
dc.contributor.author | Shukoor, M. Ibrahim | - |
dc.contributor.author | Zhu, Zhi | - |
dc.contributor.author | You, Mingxu | - |
dc.contributor.author | Tan, Xiaohong | - |
dc.contributor.author | Sanchez, Hernan | - |
dc.contributor.author | Powell, David H. | - |
dc.contributor.author | Dai, Hongjie | - |
dc.contributor.author | Tan, Weihong | - |
dc.date.accessioned | 2023-10-20T06:46:37Z | - |
dc.date.available | 2023-10-20T06:46:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of the American Chemical Society, 2010, v. 132, n. 49, p. 17408-17410 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | http://hdl.handle.net/10722/334226 | - |
dc.description.abstract | This study demonstrates the use of aptamer-conjugated graphene oxide as an affinity extraction and detection platform for analytes from complex biological media. We have shown that cocaine and adenosine can be selectively enriched from plasma samples and that direct mass spectrometric readouts can be obtained without a matrix and with greatly improved signal-to-noise ratios. Aptamer-conjugated graphene oxide has clear advantages in target enrichment and in generating highly efficient ionization of target molecules for mass spectrometry. These results demonstrate the utility of the approach for analysis of small molecules in real biological samples. © 2010 American Chemical Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of the American Chemical Society | - |
dc.title | A dual platform for selective analyte enrichment and ionization in mass spectrometry using aptamer-conjugated graphene oxide | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/ja109042w | - |
dc.identifier.pmid | 21090719 | - |
dc.identifier.scopus | eid_2-s2.0-78650128025 | - |
dc.identifier.volume | 132 | - |
dc.identifier.issue | 49 | - |
dc.identifier.spage | 17408 | - |
dc.identifier.epage | 17410 | - |
dc.identifier.eissn | 1520-5126 | - |
dc.identifier.isi | WOS:000285328800024 | - |