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Article: Multiplexed five-color molecular imaging of cancer cells and tumor tissues with carbon nanotube Raman tags in the near-infrared

TitleMultiplexed five-color molecular imaging of cancer cells and tumor tissues with carbon nanotube Raman tags in the near-infrared
Authors
KeywordsBiomedicine
Carbon nanotubes
Multiplexed imaging
Raman scattering
Issue Date2010
Citation
Nano Research, 2010, v. 3, n. 3, p. 222-233 How to Cite?
AbstractSingle-walled carbon nanotubes (SWNTs) with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity. Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs. Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor (EGFR) on LS174T colon cancer cells from cell culture to in vivo tumor growth. This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared (NIR) region under a single laser excitation. Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low, smooth autofluorescence background of biological species. © 2010 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.
Persistent Identifierhttp://hdl.handle.net/10722/334217
ISSN
2023 Impact Factor: 9.5
2023 SCImago Journal Rankings: 2.539
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Zhuang-
dc.contributor.authorTabakman, Scott-
dc.contributor.authorSherlock, Sarah-
dc.contributor.authorLi, Xiaolin-
dc.contributor.authorChen, Zhuo-
dc.contributor.authorJiang, Kaili-
dc.contributor.authorFan, Shoushan-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:46:33Z-
dc.date.available2023-10-20T06:46:33Z-
dc.date.issued2010-
dc.identifier.citationNano Research, 2010, v. 3, n. 3, p. 222-233-
dc.identifier.issn1998-0124-
dc.identifier.urihttp://hdl.handle.net/10722/334217-
dc.description.abstractSingle-walled carbon nanotubes (SWNTs) with five different C13/C12 isotope compositions and well-separated Raman peaks have been synthesized and conjugated to five targeting ligands in order to impart molecular specificity. Multiplexed Raman imaging of live cells has been carried out by highly specific staining of cells with a five-color mixture of SWNTs. Ex vivo multiplexed Raman imaging of tumor samples uncovers a surprising up-regulation of epidermal growth factor receptor (EGFR) on LS174T colon cancer cells from cell culture to in vivo tumor growth. This is the first time five-color multiplexed molecular imaging has been performed in the near-infrared (NIR) region under a single laser excitation. Near zero interfering background of imaging is achieved due to the sharp Raman peaks unique to nanotubes over the low, smooth autofluorescence background of biological species. © 2010 Tsinghua University Press and Springer-Verlag Berlin Heidelberg.-
dc.languageeng-
dc.relation.ispartofNano Research-
dc.subjectBiomedicine-
dc.subjectCarbon nanotubes-
dc.subjectMultiplexed imaging-
dc.subjectRaman scattering-
dc.titleMultiplexed five-color molecular imaging of cancer cells and tumor tissues with carbon nanotube Raman tags in the near-infrared-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s12274-010-1025-1-
dc.identifier.scopuseid_2-s2.0-77953651710-
dc.identifier.volume3-
dc.identifier.issue3-
dc.identifier.spage222-
dc.identifier.epage233-
dc.identifier.eissn1998-0000-
dc.identifier.isiWOS:000275754900008-

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