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Article: Supramolecular chemistry on water- Soluble carbon nanotubes for drug loading and delivery

TitleSupramolecular chemistry on water- Soluble carbon nanotubes for drug loading and delivery
Authors
KeywordsCarbon nanotubes
Doxorubicin
Drug delivery
Functionalization
Supramolecular chemistry
Issue Date2007
Citation
ACS Nano, 2007, v. 1, n. 1, p. 50-56 How to Cite?
AbstractWe show that large surface areas exist for supramolecular chemistry on single-walled carbon nanotubes (SWNTs) prefunctionalized noncovalently or covalently by common surfactant or acid-oxidation routes. Water-soluble SWNTs with poly(ethylene glycol) (PEG) functionalization via these routes allow for surprisingly high degrees of -stacking of aromatic molecules, including a cancer drug (doxorubicin) with ultrahigh loading capacity, a widely used fluorescence molecule (fluorescein), and combinations of molecules. Binding of molecules to nanotubes and their release can be controlled by varying the pH. The strength of -stacking of aromatic molecules is dependent on nanotube diameter, leading to a method for controlling the release rate of molecules from SWNTs by using nanotube materials with suitable diameter. This work introduces the concept of "functionalization partitioning" of SWNTs, i.e., imparting multiple chemical species, such as PEG, drugs, and fluorescent tags, with different functionalities onto the surface of the same nanotube. Such chemical partitioning should open up new opportunities in chemical, biological, and medical applications of novel nanomaterials. © 2007 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/334154
ISSN
2023 Impact Factor: 15.8
2023 SCImago Journal Rankings: 4.593
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Zhuang-
dc.contributor.authorSun, Xiaoming-
dc.contributor.authorNakayama-Ratchford, Nozomi-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:46:07Z-
dc.date.available2023-10-20T06:46:07Z-
dc.date.issued2007-
dc.identifier.citationACS Nano, 2007, v. 1, n. 1, p. 50-56-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/334154-
dc.description.abstractWe show that large surface areas exist for supramolecular chemistry on single-walled carbon nanotubes (SWNTs) prefunctionalized noncovalently or covalently by common surfactant or acid-oxidation routes. Water-soluble SWNTs with poly(ethylene glycol) (PEG) functionalization via these routes allow for surprisingly high degrees of -stacking of aromatic molecules, including a cancer drug (doxorubicin) with ultrahigh loading capacity, a widely used fluorescence molecule (fluorescein), and combinations of molecules. Binding of molecules to nanotubes and their release can be controlled by varying the pH. The strength of -stacking of aromatic molecules is dependent on nanotube diameter, leading to a method for controlling the release rate of molecules from SWNTs by using nanotube materials with suitable diameter. This work introduces the concept of "functionalization partitioning" of SWNTs, i.e., imparting multiple chemical species, such as PEG, drugs, and fluorescent tags, with different functionalities onto the surface of the same nanotube. Such chemical partitioning should open up new opportunities in chemical, biological, and medical applications of novel nanomaterials. © 2007 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofACS Nano-
dc.subjectCarbon nanotubes-
dc.subjectDoxorubicin-
dc.subjectDrug delivery-
dc.subjectFunctionalization-
dc.subjectSupramolecular chemistry-
dc.titleSupramolecular chemistry on water- Soluble carbon nanotubes for drug loading and delivery-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/nn700040t-
dc.identifier.pmid19203129-
dc.identifier.scopuseid_2-s2.0-36849063744-
dc.identifier.volume1-
dc.identifier.issue1-
dc.identifier.spage50-
dc.identifier.epage56-
dc.identifier.eissn1936-086X-
dc.identifier.isiWOS:000252012200011-

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