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Article: Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing

TitleFunctionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing
Authors
Issue Date2005
Citation
Journal of the American Chemical Society, 2005, v. 127, n. 36, p. 12492-12493 How to Cite?
AbstractWe present a novel functionalization scheme for single-walled carbon nanotubes (SWNTs) to afford nanotube-biomolecule conjugates with the incorporation of cleavable bonds to enable controlled molecular releasing from nanotube surfaces, thus creating "smart" nanomaterials with high potential for chemical and biological applications. With this versatile functionalization, we demonstrate transporting, enzymatic cleaving and releasing of DNA from SWNT transporters, and subsequent nuclear translocation of DNA oligonucleotides in mammalian cells. We further show highly efficient delivery of siRNA by SWNTs and achieving more potent RNAi functionality than a widely used conventional transfection agent. Thus, the novel functionalization of SWNTs with cleavable bonds is highly promising for a wide range of applications including gene and protein therapy. Copyright © 2005 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/334115
ISSN
2023 Impact Factor: 14.4
2023 SCImago Journal Rankings: 5.489
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKam, Nadine Wong Shi-
dc.contributor.authorLiu, Zhuang-
dc.contributor.authorDai, Hongjie-
dc.date.accessioned2023-10-20T06:45:44Z-
dc.date.available2023-10-20T06:45:44Z-
dc.date.issued2005-
dc.identifier.citationJournal of the American Chemical Society, 2005, v. 127, n. 36, p. 12492-12493-
dc.identifier.issn0002-7863-
dc.identifier.urihttp://hdl.handle.net/10722/334115-
dc.description.abstractWe present a novel functionalization scheme for single-walled carbon nanotubes (SWNTs) to afford nanotube-biomolecule conjugates with the incorporation of cleavable bonds to enable controlled molecular releasing from nanotube surfaces, thus creating "smart" nanomaterials with high potential for chemical and biological applications. With this versatile functionalization, we demonstrate transporting, enzymatic cleaving and releasing of DNA from SWNT transporters, and subsequent nuclear translocation of DNA oligonucleotides in mammalian cells. We further show highly efficient delivery of siRNA by SWNTs and achieving more potent RNAi functionality than a widely used conventional transfection agent. Thus, the novel functionalization of SWNTs with cleavable bonds is highly promising for a wide range of applications including gene and protein therapy. Copyright © 2005 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of the American Chemical Society-
dc.titleFunctionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ja053962k-
dc.identifier.pmid16144388-
dc.identifier.scopuseid_2-s2.0-24744437125-
dc.identifier.volume127-
dc.identifier.issue36-
dc.identifier.spage12492-
dc.identifier.epage12493-
dc.identifier.isiWOS:000232039100030-

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