File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells

TitlePolysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells
Authors
Keywordsbipyridinium
cancer
cytotoxicity
HeLa cells
lipid peroxidation
polysilicon microparticles
Issue Date2022
Citation
ACS Nano, 2022, v. 16, n. 4, p. 5358-5375 How to Cite?
AbstractThe use of micrometric-sized vehicles could greatly improve selectivity of cytotoxic compounds as their lack of self-diffusion could maximize their retention in tissues. We have used polysilicon microparticles (SiμP) to conjugate bipyridinium-based compounds, able to induce cytotoxicity under regular intracellular conditions. Homogeneous functionalization in suspension was achieved, where the open-chain structure exhibits a more dense packing than cyclic analogues. The microparticles internalized induce high cytotoxicity per particle in cancerous HeLa cells, and the less densely packed functionalization using cyclophanes promotes higher cytotoxicity per bipy than with open-chain analogues. The self-renewing ability of the particles and their proximity to cell membranes may account for increased lipid peroxidation, achieving toxicity at much lower concentrations than that in solution and in less time, inducing highly efficient cytotoxicity in cancerous cells.
Persistent Identifierhttp://hdl.handle.net/10722/333533
ISSN
2023 Impact Factor: 15.8
2023 SCImago Journal Rankings: 4.593
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLimón, David-
dc.contributor.authorHornick, Jessica E.-
dc.contributor.authorCai, Kang-
dc.contributor.authorBeldjoudi, Yassine-
dc.contributor.authorDuch, Marta-
dc.contributor.authorPlaza, Jose A.-
dc.contributor.authorPérez-García, Lluïsa-
dc.contributor.authorStoddart, J. Fraser-
dc.date.accessioned2023-10-06T05:20:14Z-
dc.date.available2023-10-06T05:20:14Z-
dc.date.issued2022-
dc.identifier.citationACS Nano, 2022, v. 16, n. 4, p. 5358-5375-
dc.identifier.issn1936-0851-
dc.identifier.urihttp://hdl.handle.net/10722/333533-
dc.description.abstractThe use of micrometric-sized vehicles could greatly improve selectivity of cytotoxic compounds as their lack of self-diffusion could maximize their retention in tissues. We have used polysilicon microparticles (SiμP) to conjugate bipyridinium-based compounds, able to induce cytotoxicity under regular intracellular conditions. Homogeneous functionalization in suspension was achieved, where the open-chain structure exhibits a more dense packing than cyclic analogues. The microparticles internalized induce high cytotoxicity per particle in cancerous HeLa cells, and the less densely packed functionalization using cyclophanes promotes higher cytotoxicity per bipy than with open-chain analogues. The self-renewing ability of the particles and their proximity to cell membranes may account for increased lipid peroxidation, achieving toxicity at much lower concentrations than that in solution and in less time, inducing highly efficient cytotoxicity in cancerous cells.-
dc.languageeng-
dc.relation.ispartofACS Nano-
dc.subjectbipyridinium-
dc.subjectcancer-
dc.subjectcytotoxicity-
dc.subjectHeLa cells-
dc.subjectlipid peroxidation-
dc.subjectpolysilicon microparticles-
dc.titlePolysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsnano.1c08090-
dc.identifier.pmid35357125-
dc.identifier.scopuseid_2-s2.0-85127900551-
dc.identifier.volume16-
dc.identifier.issue4-
dc.identifier.spage5358-
dc.identifier.epage5375-
dc.identifier.eissn1936-086X-
dc.identifier.isiWOS:000813129700001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats