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Article: An artificial molecular pump

TitleAn artificial molecular pump
Authors
Issue Date2015
Citation
Nature Nanotechnology, 2015, v. 10, n. 6, p. 547-553 How to Cite?
AbstractCarrier proteins consume fuel in order to pump ions or molecules across cell membranes, creating concentration gradients. Their control over diffusion pathways, effected entirely through noncovalent bonding interactions, has inspired chemists to devise artificial systems that mimic their function. Here, we report a wholly artificial compound that acts on small molecules to create a gradient in their local concentration. It does so by using redox energy and precisely organized noncovalent bonding interactions to pump positively charged rings from solution and ensnare them around an oligomethylene chain, as part of a kinetically trapped entanglement. A redox-active viologen unit at the heart of a dumbbell-shaped molecular pump plays a dual role, first attracting and then repelling the rings during redox cycling, thereby enacting a flashing energy ratchet mechanism with a minimalistic design. Our artificial molecular pump performs work repetitively for two cycles of operation and drives rings away from equilibrium toward a higher local concentration.
Persistent Identifierhttp://hdl.handle.net/10722/333123
ISSN
2023 Impact Factor: 38.1
2023 SCImago Journal Rankings: 14.577
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, Chuyang-
dc.contributor.authorMcGonigal, Paul R.-
dc.contributor.authorSchneebeli, Severin T.-
dc.contributor.authorLi, Hao-
dc.contributor.authorVermeulen, Nicolaas A.-
dc.contributor.authorKe, Chenfeng-
dc.contributor.authorStoddart, J. Fraser-
dc.date.accessioned2023-10-06T05:16:54Z-
dc.date.available2023-10-06T05:16:54Z-
dc.date.issued2015-
dc.identifier.citationNature Nanotechnology, 2015, v. 10, n. 6, p. 547-553-
dc.identifier.issn1748-3387-
dc.identifier.urihttp://hdl.handle.net/10722/333123-
dc.description.abstractCarrier proteins consume fuel in order to pump ions or molecules across cell membranes, creating concentration gradients. Their control over diffusion pathways, effected entirely through noncovalent bonding interactions, has inspired chemists to devise artificial systems that mimic their function. Here, we report a wholly artificial compound that acts on small molecules to create a gradient in their local concentration. It does so by using redox energy and precisely organized noncovalent bonding interactions to pump positively charged rings from solution and ensnare them around an oligomethylene chain, as part of a kinetically trapped entanglement. A redox-active viologen unit at the heart of a dumbbell-shaped molecular pump plays a dual role, first attracting and then repelling the rings during redox cycling, thereby enacting a flashing energy ratchet mechanism with a minimalistic design. Our artificial molecular pump performs work repetitively for two cycles of operation and drives rings away from equilibrium toward a higher local concentration.-
dc.languageeng-
dc.relation.ispartofNature Nanotechnology-
dc.titleAn artificial molecular pump-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nnano.2015.96-
dc.identifier.pmid25984834-
dc.identifier.scopuseid_2-s2.0-84930486604-
dc.identifier.volume10-
dc.identifier.issue6-
dc.identifier.spage547-
dc.identifier.epage553-
dc.identifier.eissn1748-3395-
dc.identifier.isiWOS:000355620000018-

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