File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells

TitleSynthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells
Authors
Keywordsdrug delivery
mesoporous silica
nanoparticles
RGD
transferrin
Issue Date2011
Citation
Small, 2011, v. 7, n. 13, p. 1816-1826 How to Cite?
AbstractSynthetic methodologies integrating hydrophobic drug delivery and biomolecular targeting with mesoporous silica nanoparticles are described. Transferrin and cyclic-RGD peptides are covalently attached to the nanoparticles utilizing different techniques and provide selectivity between primary and metastatic cancer cells. The increase in cellular uptake of the targeted particles is examined using fluorescence microscopy and flow cytometry. Transferrin-modified silica nanoparticles display enhancement in particle uptake by Panc-1 cancer cells over that of normal HFF cells. The endocytotic pathway for these particles is further investigated through plasmid transfection of the transferrin receptor into the normal HFF cell line, which results in an increase in particle endocytosis as compared to unmodified HFF cells. By designing and attaching a synthetic cyclic-RGD, selectivity between primary cancer cells (BT-549) and metastatic cancer cells (MDA-MB 435) is achieved with enhanced particle uptake by the metastatic cancer cell line. Incorporation of the hydrophobic drug Camptothecin into these two types of biomolecular-targeted nanoparticles causes an increase in mortality of the targeted cancer cells compared to that caused by both the free drug and nontargeted particles. These results demonstrate successful biomolecular-targeted hydrophobic drug delivery carriers that selectively target specific cancer cells and result in enhanced drug delivery and cell mortality. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/332953
ISSN
2023 Impact Factor: 13.0
2023 SCImago Journal Rankings: 3.348
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFerris, Daniel P.-
dc.contributor.authorLu, Jie-
dc.contributor.authorGothard, Chris-
dc.contributor.authorYanes, Rolando-
dc.contributor.authorThomas, Courtney R.-
dc.contributor.authorOlsen, John Carl-
dc.contributor.authorStoddart, J. Fraser-
dc.contributor.authorTamanoi, Fuyuhiko-
dc.contributor.authorZink, Jeffrey I.-
dc.date.accessioned2023-10-06T05:15:36Z-
dc.date.available2023-10-06T05:15:36Z-
dc.date.issued2011-
dc.identifier.citationSmall, 2011, v. 7, n. 13, p. 1816-1826-
dc.identifier.issn1613-6810-
dc.identifier.urihttp://hdl.handle.net/10722/332953-
dc.description.abstractSynthetic methodologies integrating hydrophobic drug delivery and biomolecular targeting with mesoporous silica nanoparticles are described. Transferrin and cyclic-RGD peptides are covalently attached to the nanoparticles utilizing different techniques and provide selectivity between primary and metastatic cancer cells. The increase in cellular uptake of the targeted particles is examined using fluorescence microscopy and flow cytometry. Transferrin-modified silica nanoparticles display enhancement in particle uptake by Panc-1 cancer cells over that of normal HFF cells. The endocytotic pathway for these particles is further investigated through plasmid transfection of the transferrin receptor into the normal HFF cell line, which results in an increase in particle endocytosis as compared to unmodified HFF cells. By designing and attaching a synthetic cyclic-RGD, selectivity between primary cancer cells (BT-549) and metastatic cancer cells (MDA-MB 435) is achieved with enhanced particle uptake by the metastatic cancer cell line. Incorporation of the hydrophobic drug Camptothecin into these two types of biomolecular-targeted nanoparticles causes an increase in mortality of the targeted cancer cells compared to that caused by both the free drug and nontargeted particles. These results demonstrate successful biomolecular-targeted hydrophobic drug delivery carriers that selectively target specific cancer cells and result in enhanced drug delivery and cell mortality. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.relation.ispartofSmall-
dc.subjectdrug delivery-
dc.subjectmesoporous silica-
dc.subjectnanoparticles-
dc.subjectRGD-
dc.subjecttransferrin-
dc.titleSynthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/smll.201002300-
dc.identifier.pmid21595023-
dc.identifier.scopuseid_2-s2.0-79959860212-
dc.identifier.volume7-
dc.identifier.issue13-
dc.identifier.spage1816-
dc.identifier.epage1826-
dc.identifier.eissn1613-6829-
dc.identifier.isiWOS:000293026900010-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats