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Article: The complexation properties of some unnatural and natural macrocyclic trichothecenes

TitleThe complexation properties of some unnatural and natural macrocyclic trichothecenes
Authors
Anderson, Derek W.Ashton, Peter R.Black, Robin M.Leigh, David A.Slawin, Alexandra M.Z.Stoddart, J. FraserWilliams, David J.
Issue Date1988
Citation
Journal of the Chemical Society, Chemical Communications, 1988, n. 13, p. 904-908 How to Cite?
DOI: http://dx.doi.org/10.1039/C39880000904
AbstractAs a result of investigating the complexing properties of a series of novel polyether analogues (3)-(9) of macrocyclic trichothecenes towards alkali metal cations and RNH3+ ions, it has been proposed, with supporting evidence from X-ray crystallography on verrucarin A (1) and fast atom bombardment mass spectrometry of complexes involving (1) and the triacetate (10) of baccharinol B4 (11), that the enhanced biological activities of macrocyclic trichothecenes, such as (1) and (11), compared with non-macrocyclic trichoverroids such as (2), may be a consequence of their abilities to bind to NH3+ ionic sites on proteins, particularly those associated with the 60S ribosomes.
Persistent Identifierhttp://hdl.handle.net/10722/332774
ISSN
0022-4936
ISI Accession Number ID
WOS:A1988P286300038

 

DC FieldValueLanguage
dc.contributor.authorAnderson, Derek W.-
dc.contributor.authorAshton, Peter R.-
dc.contributor.authorBlack, Robin M.-
dc.contributor.authorLeigh, David A.-
dc.contributor.authorSlawin, Alexandra M.Z.-
dc.contributor.authorStoddart, J. Fraser-
dc.contributor.authorWilliams, David J.-
dc.date.accessioned2023-10-06T05:14:10Z-
dc.date.available2023-10-06T05:14:10Z-
dc.date.issued1988-
dc.identifier.citationJournal of the Chemical Society, Chemical Communications, 1988, n. 13, p. 904-908-
dc.identifier.issn0022-4936-
dc.identifier.urihttp://hdl.handle.net/10722/332774-
dc.description.abstractAs a result of investigating the complexing properties of a series of novel polyether analogues (3)-(9) of macrocyclic trichothecenes towards alkali metal cations and RNH<inf>3</inf><sup>+</sup> ions, it has been proposed, with supporting evidence from X-ray crystallography on verrucarin A (1) and fast atom bombardment mass spectrometry of complexes involving (1) and the triacetate (10) of baccharinol B4 (11), that the enhanced biological activities of macrocyclic trichothecenes, such as (1) and (11), compared with non-macrocyclic trichoverroids such as (2), may be a consequence of their abilities to bind to NH<inf>3</inf><sup>+</sup> ionic sites on proteins, particularly those associated with the 60S ribosomes.-
dc.languageeng-
dc.relation.ispartofJournal of the Chemical Society, Chemical Communications-
dc.titleThe complexation properties of some unnatural and natural macrocyclic trichothecenes-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/C39880000904-
dc.identifier.scopuseid_2-s2.0-37049087900-
dc.identifier.issue13-
dc.identifier.spage904-
dc.identifier.epage908-
dc.identifier.isiWOS:A1988P286300038-

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