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- Publisher Website: 10.1016/j.chembiol.2007.09.007
- Scopus: eid_2-s2.0-35349011634
- PMID: 17961826
- WOS: WOS:000250602200007
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Article: Multivalent Interactions between Lectins and Supramolecular Complexes: Galectin-1 and Self-Assembled Pseudopolyrotaxanes
Title | Multivalent Interactions between Lectins and Supramolecular Complexes: Galectin-1 and Self-Assembled Pseudopolyrotaxanes |
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Authors | |
Keywords | CHEMBIO |
Issue Date | 2007 |
Citation | Chemistry and Biology, 2007, v. 14, n. 10, p. 1140-1151 How to Cite? |
Abstract | Supramolecular chemistry has been employed to develop flexible and adaptable multivalent neoglycoconjugates for binding galectin-1 (Gal-1). Gal-1, a dimeric lectin with two galactoside-binding sites, regulates cancer progression and immune responses. Self-assembled pseudopolyrotaxanes consisting of lactoside-displaying cyclodextrin (LCD) "beads" threaded onto polyviologen "strings" display mobile ligands as a result of cyclodextrin rotation about, and limited translation along, the polymer chain. The pseudopolyrotaxanes rapidly and efficiently precipitate Gal-1 and provide valency-corrected enhancements of up to 30-fold compared to native lactose and 20-fold over free LCD in a T-cell agglutination assay. A supramolecular statistical effect was observed, wherein the efficacy of Gal-1 inhibition correlates with the number of ligands connected to each other solely through mechanical and noncovalent interactions. Such flexible and adaptable self-assembled pseudopolyrotaxanes show promise for the study of multivalent interactions and targeting of therapeutically relevant lectins. © 2007 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/332748 |
ISSN | 2017 Impact Factor: 5.915 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Belitsky, Jason M. | - |
dc.contributor.author | Nelson, Alshakim | - |
dc.contributor.author | Hernandez, Joseph D. | - |
dc.contributor.author | Baum, Linda G. | - |
dc.contributor.author | Stoddart, J. Fraser | - |
dc.date.accessioned | 2023-10-06T05:13:58Z | - |
dc.date.available | 2023-10-06T05:13:58Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Chemistry and Biology, 2007, v. 14, n. 10, p. 1140-1151 | - |
dc.identifier.issn | 1074-5521 | - |
dc.identifier.uri | http://hdl.handle.net/10722/332748 | - |
dc.description.abstract | Supramolecular chemistry has been employed to develop flexible and adaptable multivalent neoglycoconjugates for binding galectin-1 (Gal-1). Gal-1, a dimeric lectin with two galactoside-binding sites, regulates cancer progression and immune responses. Self-assembled pseudopolyrotaxanes consisting of lactoside-displaying cyclodextrin (LCD) "beads" threaded onto polyviologen "strings" display mobile ligands as a result of cyclodextrin rotation about, and limited translation along, the polymer chain. The pseudopolyrotaxanes rapidly and efficiently precipitate Gal-1 and provide valency-corrected enhancements of up to 30-fold compared to native lactose and 20-fold over free LCD in a T-cell agglutination assay. A supramolecular statistical effect was observed, wherein the efficacy of Gal-1 inhibition correlates with the number of ligands connected to each other solely through mechanical and noncovalent interactions. Such flexible and adaptable self-assembled pseudopolyrotaxanes show promise for the study of multivalent interactions and targeting of therapeutically relevant lectins. © 2007 Elsevier Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Chemistry and Biology | - |
dc.subject | CHEMBIO | - |
dc.title | Multivalent Interactions between Lectins and Supramolecular Complexes: Galectin-1 and Self-Assembled Pseudopolyrotaxanes | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.chembiol.2007.09.007 | - |
dc.identifier.pmid | 17961826 | - |
dc.identifier.scopus | eid_2-s2.0-35349011634 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 1140 | - |
dc.identifier.epage | 1151 | - |
dc.identifier.isi | WOS:000250602200007 | - |