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Article: Amino acid derivatives of β-cyclodextrin

TitleAmino acid derivatives of β-cyclodextrin
Authors
Ashton, Peter R.Königer, RainerStoddart, J. FraserAlker, DavidHarding, Valerie D.
Issue Date1996
Citation
Journal of Organic Chemistry, 1996, v. 61, n. 3, p. 903-908 How to Cite?
DOI: http://dx.doi.org/10.1021/jo951396d
AbstractThe syntheses of the heptaamino acid-substituted β-cyclodextrins per-6-[(phenylalanyl)amino]-β-cyclodextrin (6), per-6-cysteinyl-β-cyclodextrin (7), as well as the per-2,3-dimethyl-per-6-cysteinyl-β-cyclodextrin (12) are described. The amino acids were coupled to the primary face of the β-cyclodextrin torus using the backbone carboxylic acid functionality of phenylalanine and the side chain thiol group of cysteine. In the case of the heptacysteinyl derivatives, polyzwitterionic compounds were obtained and shown to be highly water soluble.
Persistent Identifierhttp://hdl.handle.net/10722/332383
ISSN
0022-3263
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.724
ISI Accession Number ID
WOS:A1996TV53900017

 

DC FieldValueLanguage
dc.contributor.authorAshton, Peter R.-
dc.contributor.authorKöniger, Rainer-
dc.contributor.authorStoddart, J. Fraser-
dc.contributor.authorAlker, David-
dc.contributor.authorHarding, Valerie D.-
dc.date.accessioned2023-10-06T05:11:02Z-
dc.date.available2023-10-06T05:11:02Z-
dc.date.issued1996-
dc.identifier.citationJournal of Organic Chemistry, 1996, v. 61, n. 3, p. 903-908-
dc.identifier.issn0022-3263-
dc.identifier.urihttp://hdl.handle.net/10722/332383-
dc.description.abstractThe syntheses of the heptaamino acid-substituted β-cyclodextrins per-6-[(phenylalanyl)amino]-β-cyclodextrin (6), per-6-cysteinyl-β-cyclodextrin (7), as well as the per-2,3-dimethyl-per-6-cysteinyl-β-cyclodextrin (12) are described. The amino acids were coupled to the primary face of the β-cyclodextrin torus using the backbone carboxylic acid functionality of phenylalanine and the side chain thiol group of cysteine. In the case of the heptacysteinyl derivatives, polyzwitterionic compounds were obtained and shown to be highly water soluble.-
dc.languageeng-
dc.relation.ispartofJournal of Organic Chemistry-
dc.titleAmino acid derivatives of β-cyclodextrin-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/jo951396d-
dc.identifier.scopuseid_2-s2.0-0030024976-
dc.identifier.volume61-
dc.identifier.issue3-
dc.identifier.spage903-
dc.identifier.epage908-
dc.identifier.isiWOS:A1996TV53900017-

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