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Article: Digital Light Processing (DLP) of Nano Biphasic Calcium Phosphate Bioceramic for Making Bone Tissue Engineering Scaffolds

TitleDigital Light Processing (DLP) of Nano Biphasic Calcium Phosphate Bioceramic for Making Bone Tissue Engineering Scaffolds
Authors
Keywords3D printing
Bone scaffold
Digital light processing
Nano biphasic calcium phosphate
Sintering temperature
Issue Date1-Oct-2022
PublisherElsevier
Citation
Ceramics International, 2022, v. 48, n. 19, p. 27681-27692 How to Cite?
Abstract

Nano-sized ceramic particles are beneficial for the properties of 3D printed structures via digital light processing (DLP). However, achieving optimal conditions for the preparation and processing of ceramic nanoparticle-based slurry is a significant challenge. In this work, a stable and well dispersed slurry with nano-sized biphasic calcium phosphate (BCP) powders was developed and porous BCP bioceramic scaffolds with good bioactivity were accurately fabricated via the DLP additive manufacturing technology. Effects of dispersant, photoinitiator and solid loading on rheological properties and curing abilities of BCP slurries were systematically studied. The slurry having 65 wt % of nano-sized BCP powders showed a relatively low viscosity of 400 mPa s at the 50 s−1 shear rate. It was found that the optimal photoinitiator concentration was tightly associated with the energy dosage in DLP. Furthermore, the effects of sintering temperature (1100 °C, 1200 °C and 1300 °C) on the surface morphology, shrinkage, phase constitution, hardness, compressive properties, and in vitro biological performance of DLP-formed bioceramics were comprehensively investigated. The results showed that DLP-formed BCP ceramics sintered at 1300 °C had the best mechanical propertiesin vitro cytocompatibility, and homogeneous bone-like apatite formation ability. Finally, DLP-formed 3D scaffolds with different pore sizes ranging from 300 μm to 1 mm were successfully fabricated, which exhibited high fidelity and accuracy. The current study has demonstrated the great potential of using DLP technology to construct functional complex BCP bioceramic scaffolds for bone tissue regeneration.


Persistent Identifierhttp://hdl.handle.net/10722/332237
ISSN
2023 Impact Factor: 5.1
2023 SCImago Journal Rankings: 0.938
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Y-
dc.contributor.authorChen, SS-
dc.contributor.authorLiang, HW-
dc.contributor.authorLiu, Y-
dc.contributor.authorBai, JM-
dc.contributor.authorWang, M-
dc.date.accessioned2023-10-04T07:21:09Z-
dc.date.available2023-10-04T07:21:09Z-
dc.date.issued2022-10-01-
dc.identifier.citationCeramics International, 2022, v. 48, n. 19, p. 27681-27692-
dc.identifier.issn0272-8842-
dc.identifier.urihttp://hdl.handle.net/10722/332237-
dc.description.abstract<p>Nano-sized ceramic particles are beneficial for the properties of 3D printed structures via digital light processing (DLP). However, achieving optimal conditions for the preparation and processing of ceramic nanoparticle-based slurry is a significant challenge. In this work, a stable and well dispersed slurry with nano-sized <a href="https://www.sciencedirect.com/topics/materials-science/biphasic-calcium-phosphate" title="Learn more about biphasic calcium phosphate from ScienceDirect's AI-generated Topic Pages">biphasic calcium phosphate</a> (BCP) powders was developed and porous BCP <a href="https://www.sciencedirect.com/topics/materials-science/bioceramic" title="Learn more about bioceramic from ScienceDirect's AI-generated Topic Pages">bioceramic</a> scaffolds with good bioactivity were accurately fabricated via the DLP <a href="https://www.sciencedirect.com/topics/materials-science/three-dimensional-printing" title="Learn more about additive manufacturing from ScienceDirect's AI-generated Topic Pages">additive manufacturing</a> technology. Effects of dispersant, photoinitiator and solid loading on rheological properties and curing abilities of BCP slurries were systematically studied. The slurry having 65 wt % of nano-sized BCP powders showed a relatively low viscosity of 400 mPa s at the 50 s<sup>−1</sup> shear rate. It was found that the optimal photoinitiator concentration was tightly associated with the energy dosage in DLP. Furthermore, the effects of <a href="https://www.sciencedirect.com/topics/materials-science/sintering-temperature" title="Learn more about sintering temperature from ScienceDirect's AI-generated Topic Pages">sintering temperature</a> (1100 °C, 1200 °C and 1300 °C) on the <a href="https://www.sciencedirect.com/topics/materials-science/surface-morphology" title="Learn more about surface morphology from ScienceDirect's AI-generated Topic Pages">surface morphology</a>, shrinkage, phase constitution, hardness, compressive properties, and <em>in vitro</em> biological performance of DLP-formed bioceramics were comprehensively investigated. The results showed that DLP-formed BCP ceramics sintered at 1300 °C had the best <a href="https://www.sciencedirect.com/topics/materials-science/mechanical-property" title="Learn more about mechanical properties from ScienceDirect's AI-generated Topic Pages">mechanical properties</a>, <em>in vitro</em> cytocompatibility, and homogeneous bone-like <a href="https://www.sciencedirect.com/topics/materials-science/apatite" title="Learn more about apatite from ScienceDirect's AI-generated Topic Pages">apatite</a> formation ability. Finally, DLP-formed 3D scaffolds with different pore sizes ranging from 300 μm to 1 mm were successfully fabricated, which exhibited high fidelity and accuracy. The current study has demonstrated the great potential of using DLP technology to construct functional complex BCP <a href="https://www.sciencedirect.com/topics/materials-science/bioceramic" title="Learn more about bioceramic from ScienceDirect's AI-generated Topic Pages">bioceramic</a> scaffolds for bone tissue regeneration.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofCeramics International-
dc.subject3D printing-
dc.subjectBone scaffold-
dc.subjectDigital light processing-
dc.subjectNano biphasic calcium phosphate-
dc.subjectSintering temperature-
dc.titleDigital Light Processing (DLP) of Nano Biphasic Calcium Phosphate Bioceramic for Making Bone Tissue Engineering Scaffolds-
dc.typeArticle-
dc.identifier.doi10.1016/j.ceramint.2022.06.067-
dc.identifier.scopuseid_2-s2.0-85132503648-
dc.identifier.volume48-
dc.identifier.issue19-
dc.identifier.spage27681-
dc.identifier.epage27692-
dc.identifier.eissn1873-3956-
dc.identifier.isiWOS:000883815300002-
dc.identifier.issnl0272-8842-

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